Effect of seeded surface area on crystal size distribution in glycine batch cooling crystallization: A seeding methodology

In batch cooling crystallization, if the seeding process is not carefully carried out, the crystal size distribution (CSD) is dispersed. The aim of this work is to determine the optimal conditions for seeding operations. Results show that the CSD is controlled if the seed surface area reaches a specific value called critical surface Sc. Nevertheless, Sc is not the only parameter to be considered. The mean crystal size of the product obtained actually depends on the size of the seeds used because of the growth rate distribution. In fact, seeds behave differently according to their crystal sizes, which accounts for the difference in crystal growth rates. Rules are proposed for seeding with the view to obtain a uni-modal CSD and a final product size predefined by the seed crystals. © 2004 Elsevier B.V. All rights reserved.

A1. Secondary nucleation; A2. Batch cooling crystallization; A2. Seed surface area; A2. Seeding methodology; B2. Glycine Cloud seeding; Cooling; Crystal growth; Crystal structure; Drug products; Drying; Filtration; Nucleation; Batch cooling crystallization; Glycine; Secondary nucleation; Seed surface area; Seeding methodology; Crystallization

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