Use of organogel-based emulsions (o/w) as a tool to increase the bioaccessibility of lupeol, curcumin, and quercetin Article uri icon

abstract

  • Lupeol, curcumin, and quercetin are naturally occurring compounds present in plants, with some beneficial health effects. In the present study, organogel-based emulsions (o/w) were obtained from edible oils to increase their bioaccessibility and intestinal permeability. Particle size analysis, rheology test, optical microscopy, in vitro digestibility, and permeability of nutraceuticals by cell culture and UPLC-MS/MS were performed. Particle hydrodynamic diameters obtained in organogel-based emulsions loaded with nutraceuticals were <200 nm, polydispersity index was around 0.25–0.4, and zeta potential was about −19 to −25 mV. Droplets in emulsions presented spherical shapes and adjusted to the Herschel–Bulkley model. Interestingly, bioaccessibility and intestinal permeability of lupeol was increased compared with its crystalline form, opposite to the observed for curcumin and quercetin; therefore, organogel-based emulsions loaded with lupeol have potential for controlled oral delivery of this nutraceutical. © 2021 AOCS.

publication date

  • 2021-01-01