Evaluation of the acute toxicity of an alcoholic extract from tarbush leaves (Flourensia cernua) [Evaluación de la toxicidad aguda de un extracto alcohólico de hojas de hojasén (Flourensia cernua)]

Flourensia cernua (tarbush) is a plant traditionally used by the Mexican population for gastrointestinal disorders. The proposal of this study was to evaluate the acute toxicity of an extract of the plant using the alternative method Fixed Dose Procedure (FDP). A single dose of 2000 mg/kg body weight of the extract was given by oral route to a group of five Wistar rats; a control group was treated with 0.85%25 sodium chloride. Although there were signs of slight toxicity on the test group, there were no animals deaths, the body weight behaved normal and studies showed no gross pathological changes in organs. The extract LD50was above 2000 mg/kg.

Fixed dose procedure; Flourensia cernua; Tarbush; Toxicity of plants Flourensia cernua extract; plant extract; sodium chloride; unclassified drug; acute toxicity; animal experiment; article; body weight; controlled study; LD 50; nonhuman; pathology; plant leaf; rat; single drug dose; Wistar rat

VIVO