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White matter injury in a newborn rat model analyzed with Resting-State Optical Imaging of Intrinsic Signals (rsOIS)
Using rsOIS (Resting-State Optical Imaging of Intrinsic Signals), we demonstrated a non-invasive approach to assess cerebral changes in response to inflammatory white matter injury. Surprisingly, lipopolysaccharide (LPS) exposure induced an increase in inter-hemispheric functional connectivity (fc); this may reflect a possible compensatory mechanism to overcome the effects of inflammatory insult. © 2015 IEEE.
brain injury; newborn; optical imaging; rodent Imaging techniques; Brain injury; Functional connectivity; Intrinsic signal; Lipopolysaccharides; newborn; Optical imaging; Resting state; rodent; Optical image storage
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