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Continuant
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Review
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RDF description of Regulation of miRNAs Expression by Mutant p53 Gain of Function in Cancer - http://orbis.uaslp.mx/vivo/individual/scopus9635
rights: termsOfUse
date: 2026-08-27T18:28:36
publisher: vivo
type: Document

Regulation of miRNAs Expression by Mutant p53 Gain of Function in Cancer
origen: scopus
most specific type: Review
related by: authorship_66884
doi: 10.3389/fcell.2021.695723
type: Thing
freetext keyword: cancer; gain of function; miRNA biogenesis; miRNAs; mutant p53
volume: 9
type: Document
crisid: 9636
accesstype: All Open Access, Gold, Green
has publication venue: Frontiers in Cell and Developmental Biology
type: Generically Dependent Continuant
most specific type: Document
type: Continuant
type: Article
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e iscopus: 2-s2.0-85121682942
date time value: review date 9636
related by: authorship_66885
estado: published
artnum: 695723
type: Entity
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 168896, 261875
abstract: The p53 roles have been largely described; among them, cell proliferation and apoptosis control are some of the best studied and understood. Interestingly, the mutations on the six hotspot sites within the region that encodes the DNA-binding domain of p53 give rise to other very different variants. The particular behavior of these variants led to consider p53 mutants as separate oncogene entities; that is, they do not retain wild type functions but acquire new ones, namely Gain-of-function p53 mutants. Furthermore, recent studies have revealed how p53 mutants regulate gene expression and exert oncogenic effects by unbalancing specific microRNAs (miRNAs) levels that provoke epithelial-mesenchymal transition, chemoresistance, and cell survival, among others. In this review, we discuss recent evidence of the crosstalk between miRNAs and mutants of p53, as well as the consequent cellular processes dysregulated. Copyright © 2021 Madrigal, Hernández-Monge, Herrera, González-De la Rosa, Domínguez-Gómez, Candelaria, Luna-Maldonado, Calderón González and Díaz-Chávez.
type: Review

Article
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Consejo Nacional de Ciencia y Tecnología, CONACYT: 168896, 261875
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type: BFO_0000020
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type: Grant
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funding vehicle for: Regulation of miRNAs Expression by Mutant p53 Gain of Function in Cancer

Information Content Entity
type: Class

Frontiers in Cell and Developmental Biology
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type: Document
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type: Generically Dependent Continuant
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type: Journal
publication venue for: Regulation of miRNAs Expression by Mutant p53 Gain of Function in Cancer