Document
type: Class

Presence of sars-cov-2 and its entry factors in oral tissues and cells: A systematic review
related by: authorship_64891
has publication venue: Medicina (Lithuania)
volume: 57
type: Article
type: Information Content Entity
type: Document
related by: authorship_64893
doi: 10.3390/medicina57060523
artnum: 523
related by: authorship_64892
abstract: Background and Objectives: The aim of this systematic review is to summarize the current data about the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its entry factors in oral tissues and cells. Materials and Methods: This systematic review was carried out based on the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA). Three databases were analyzed (Pubmed, Web of science and Scopus) by three independent researchers. From the 18 identified studies, 10 of them met the inclusion criteria. The presence of SARS-CoV-2 or its entry factors (angiotensin-converting enzyme II (ACE2), transmembrane serine proteases (TMPRSS), and furin) was analyzed in these 10 studies during the pandemic. Results: ACE2 expression was analyzed in 9 of the 10 studies. ACE2 is expressed mainly in the tongue, oral mucosa, salivary glands and epithelial cells. The expression of the TMPRSS2 gene or protein was analyzed in 6 studies. These studies reported that the expression of TMPRSS2 was mainly in the salivary glands, tongue, sulcular epithelium and oral mucosa; as well as in cells of the salivary glands (ductal, acinar and myoepithelial cells) and the tongue (the spinous-based cell layer, horny layer and the epithelial surface). Other TMPRSS were also reported. The expression of TMPRSS3, TMPRSS4, TMPRSS5, TMPRSS7 and TMPRSS11D was reported mainly in salivary glands and in epithelial-type cells. Furan expression was analyzed in three studies. The expression of furin was detected mainly in epithelial cells of the tongue. A variety of methods were used to carry out the detection of SARS-CoV-2 or its input molecules. Conclusions: These results show that SARS-CoV-2 can infect a wide variety of oral tissues and cells, and that together with the theories dedicated to explaining the oral symptoms present in SARS-CoV-2 positive patients, it provides us with a good scientific basis for understanding the virus infection in the oral cavity and its co…
accesstype: All Open Access, Gold, Green
origen: scopus
has funding vehicle: Benemérita Universidad Autónoma de Puebla, BUAP
related by: authorship_64890
chemicalscas: furin; proprotein convertase 9; serine protease HTRA1; serine proteinase, 37259-58-8; Furin; Membrane Proteins; Neoplasm Proteins; Serine Endopeptidases; TMPRSS3 protein, human; TMPRSS4 protein, human
most specific type: Document
type: Continuant
type: Entity
e iscopus: 2-s2.0-85107269378
pmid: 34070998
type: Generically Dependent Continuant
estado: published
type: Thing
most specific type: Article
date time value: article date 9098
freetext keyword: ACE2; COVID-19; Entry factors; Furin; Oral tissues; SARS-CoV-2; TMPRSS furin; membrane protein; serine proteinase; TMPRSS3 protein, human; TMPRSS4 protein, human; tumor protein; human; meta analysis; mouth mucosa; pandemic; COVID-19; Furin; Humans; Membrane Proteins; Mouth Mucosa; Neoplasm Proteins; Pandemics; SARS-CoV-2; Serine Endopeptidases
crisid: 9098
issue: 6

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RDF description of Presence of sars-cov-2 and its entry factors in oral tissues and cells: A systematic review - http://orbis.uaslp.mx/vivo/individual/scopus9097
rights: termsOfUse
date: 2026-08-25T22:03:56
publisher: vivo
type: Document

Benemérita Universidad Autónoma de Puebla, BUAP
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Presence of sars-cov-2 and its entry factors in oral tissues and cells: A systematic review

Article
type: Class

Information Content Entity
type: Class

Medicina (Lithuania)
type: Information Content Entity
type: Generically Dependent Continuant
type: Document
type: Collection
publication venue for: Presence of sars-cov-2 and its entry factors in oral tissues and cells: A systematic review
type: Entity
type: Periodical
type: Continuant
type: Journal
type: Thing