Document
Generically Dependent Continuant
Synthesis of a PVA drug delivery system for controlled release of a Tramadol–Dexketoprofen combination
polyvinyl alcohol, 37380-95-3, 9002-89-5; ketoprofen, 22071-15-4, 57495-14-4; tramadol, 27203-92-5, 36282-47-0; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Drug Combinations; Ketoprofen; Membranes, Artificial; Polyvinyl Alcohol; Tramadol; tramadol, dexketoprofen drug combination
The local administration of analgesic combinations by means of degradable polymeric drug delivery systems is an alternative for the management of postoperative pain. We formulated a Tramadol–Dexketoprofen combination (TDC) loaded in poly(vinyl alcohol) (PVA) film. Films were prepared by the solvent casting method using three different molecular weights of PVA and crosslinking those films with citric acid, with the objective of controlling the drug release rate, which was evaluated by UV–vis spectrometry. Non-crosslinked PVA films were also evaluated in the experiments. Differential scanning calorimetry (DSC) analysis of samples corroborated the crosslinking of PVA by the citric acid. Blank and loaded PVA films were tested in vitro for its impact on blood coagulation prothrombin time (PT) and partial thromboplastin time (PTT). The swelling capacity was also evaluated. Crosslinked PVA films of higher-molecular weight showed a prolonged release rate compared with that of the lower-molecular-weight films tested. Non-crosslinked PVA films released 11–14%25 of TDC. Crosslinked PVA films released 80%25 of the TDC loaded (p < 0.05). This suggests that crosslinking films can modify the drug release rate. The blank and loaded PVA films induced PT and PTT in the normal range. The results showed that the polymeric films evaluated here have the appropriate properties to allow films to be placed directly on surgical wounds and have the capacity for controlled drug release to promote local analgesia for the control of postoperative pain. [Figure not available: see fulltext.] © 2021, The Author(s).
Citric acid; Differential scanning calorimetry; Drug products; Molecular weight; Polyvinyl alcohols; Swelling; Targeted drug delivery; Controlled drug release; Controlled release; Crosslinking films; Drug delivery system; Poly (vinyl alcohol) (PVA); Polymeric drug delivery system; Solvent casting method; Swelling capacities; Controlled drug delivery; dexketoprofen plus tramadol; polyvinyl alcohol; ketoprofen; narcotic analgesic agent; nonsteroid antiinflammatory agent; tramadol; tramadol, dexketoprofen drug combination; analgesia; Article; blood clotting; cross linking; differential scanning calorimetry; drug delivery system; in vitro study; molecular weight; partial thromboplastin time; postoperative pain; priority journal; prothrombin time; scanning electron microscopy; surgical wound; swelling; ultraviolet spectroscopy; adult; artificial membrane; chemistry; delayed release formulation; drug combination; drug release; human; infrared spectroscopy; male; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Drug Combinations; Drug Delivery Systems; Drug Liberation; Humans; Ketoprofen; Male; Membranes, Artificial; Partial Thromboplastin Time; Polyvinyl Alcohol; Prothrombin Time; Spectroscopy, Fourier Transform Infrared; Tramadol
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Article
Journal of Materials Science: Materials in Medicine
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