Clinica Chimica Acta
type: Periodical
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type: Generically Dependent Continuant
publication venue for: Comparative analysis of chemical breath-prints through olfactory technology for the discrimination between SARS-CoV-2 infected patients and controls
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Comparative analysis of chemical breath-prints through olfactory technology for the discrimination between SARS-CoV-2 infected patients and controls
related by: authorship_64655
page start: 126
type: Entity
type: Generically Dependent Continuant
freetext keyword: Asymptomatic; COVID-19 screening; Electronic nose; Exhaled breath; Volatile organic compounds adult; Article; asymptomatic infection; clinical article; comparative study; controlled study; coronavirus disease 2019; female; human; male; olfactory discrimination; prediction; public health; screening test; sensitivity and specificity; virus transmission; mass screening; technology; COVID-19; Humans; Mass Screening; SARS-CoV-2; Sensitivity and Specificity; Technology
estado: published
type: Thing
most specific type: Article
related by: authorship_64663
type: Document
doi: 10.1016/j.cca.2021.04.015
date time value: article date 9038
related by: authorship_64657
volume: 519
type: Continuant
origen: scopus
related by: authorship_64659
related by: authorship_64661
related by: authorship_64662
crisid: 9038
related by: authorship_64656
type: Article
has publication venue: Clinica Chimica Acta
accesstype: All Open Access, Bronze, Green
pmid: 33901429
page end: 132
related by: authorship_64660
e iscopus: 2-s2.0-85104980513
type: Information Content Entity
abstract: Background: We identified a global chemical pattern of volatile organic compounds in exhaled breath capable of discriminating between COVID-19 patients and controls (without infection) using an electronic nose. Methods: The study focused on 42 SARS-CoV-2 RT-qPCR positive subjects as well as 42 negative subjects. Principal component analysis indicated a separation of the study groups and provides a cumulative percentage of explanation of the variation of 98.3%25. Results: The canonical analysis of principal coordinates model shows a separation by the first canonical axis CAP1 (r2 = 0.939 and 95.23%25 of correct classification rate), the cut-off point of 0.0089; 100%25 sensitivity (CI 95%25:91.5–100%25) and 97.6%25 specificity (CI 95%25:87.4–99.9%25). The predictive model usefulness was tested on 30 open population subjects without prior knowledge of SARS-CoV-2 RT-qPCR status. Of these 3 subjects exhibited COVID-19 suggestive breath profiles, all asymptomatic at the time, two of which were later shown to be SARS-CoV-2 RT-qPCR positive. An additional subject had a borderline breath profile and SARS-CoV-2 RT-qPCR positive. The remaining 27 subjects exhibited healthy breath profiles as well as SARS-CoV-2 RT-qPCR test results. Conclusions: In all, the use of olfactory technologies in communities with high transmission rates as well as in resource-limited settings where targeted sampling is not viable represents a practical COVID-19 screening approach capable of promptly identifying COVID-19 suspect patients and providing useful epidemiological information to guide community health strategies in the context of COVID-19. © 2021 Elsevier B.V.
most specific type: Document
related by: authorship_64658

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rights: termsOfUse
date: 2026-08-24T21:51:08
publisher: vivo
type: Document
label: RDF description of Comparative analysis of chemical breath-prints through olfactory technology for the discrimination between SARS-CoV-2 infected patients and controls - http://orbis.uaslp.mx/vivo/individual/scopus9037

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