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type: Class

Co-stimulatory signals increase the reactivity of T cells towards mycobacterial antigens
related by: authorship 4251
type: Information Content Entity
type: Generically Dependent Continuant
related by: authorship 4254
related by: authorship 4256
date time value: article date 864
type: Continuant
related by: authorship 4253
type: Entity
chemicalscas: Antibodies, Monoclonal; Antigens, Bacterial; Antigens, CD; Antigens, CD7; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; CD69 antigen; CDw50 antigen, human; Cell Adhesion Molecules; Interleukin-10, 130068-27-8; Lymphocyte Function-Associated Antigen-1; Receptors, Antigen, T-Cell, gamma-delta
page end: 475
has publication venue: Clinical and Experimental Immunology
related by: authorship 4255
type: Article
page start: 468
origen: scopus
doi: 10.1046/j.1365-2249.2000.01226.x
type: Document
most specific type: Document
pmid: 10844525
accesstype: All Open Access, Bronze, Green
related by: authorship 4250
related by: authorship 4249
e iscopus: 2-s2.0-0034122102
type: Thing
crisid: 864
estado: published
freetext keyword: γΔ T cells; Leprosy; Mycobacteria; T lymphocytes; Tuberculosis antigen; CD28 antigen; glycoprotein; interleukin 10; antibody specificity; article; cell membrane; cell proliferation; centrifugation; clinical article; controlled study; human; human cell; leprosy; priority journal; signal transduction; T lymphocyte; T lymphocyte activation; tuberculosis; Antibodies, Monoclonal; Antigens, Bacterial; Antigens, CD; Antigens, CD7; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; Cell Adhesion Molecules; Cell Division; Cell Separation; Cells, Cultured; Flow Cytometry; Humans; Interleukin-10; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Mycobacterium; Receptors, Antigen, T-Cell, gamma-delta; Signal Transduction; T-Lymphocytes
volume: 120
abstract: Although it has been shown that γδ T lymphocytes are able to react with different cell-associated or soluble antigens, the immune repertoire of these cells appears to be skewed to the recognition of mycobacterial antigens. We have studied the number and reactivity of γδ T cells towards several mycobacterial antigens in patients with tuberculosis and leprosy, as well as their healthy contacts and control individuals. We found an increased number of Vδ2%2b cells in healthy contacts (PPD%2b and lepromin%2b) and tuberculoid leprosy patients. The γδS T cells from lepromatous leprosy showed a decreased response to all antigens tested, but some of these patients exhibited a significant response to the 30-kD glycoprotein of Mycobacterium tuberculosis. Interestingly, the reactivity of γδ T cells against mycobacterial antigens was significantly increased by costimulatory signals generated through CD7, LFA-1, CD50 and CD69 in all groups. However, signalling through CD69 did not enhance the responsiveness of γδ lymphocytes from lepromatous patients. On the other hand, the in vitro blockade of IL-10 with a specific antibody enhanced the cell proliferation of γδ lymphocytes from lepromatous leprosy patients, whereas exogenous IL-10 had an opposite effect in most individuals studied. These results suggest the potential role of different cell membrane receptors in the regulation of γδ T cell proliferation induced by mycobacteria, as well as the possible involvement of IL-10 in this phenomenon.
related by: authorship 4252
abstract: Although it has been shown that γδ T lymphocytes are able to react with different cell-associated or soluble antigens, the immune repertoire of these cells appears to be skewed to the recognition of mycobacterial antigens. We have studied the number and reactivity of γδ T cells towards several mycobacterial antigens in patients with tuberculosis and leprosy, as well as their healthy contacts and control individuals. We found an increased number of Vδ2 cells in healthy contacts (PPD and lepromin ) and tuberculoid leprosy patients. The γδS T cells from lepromatous leprosy showed a decreased response to all antigens tested, but some of these patients exhibited a significant response to the 30-kD glycoprotein of Mycobacterium tuberculosis. Interestingly, the reactivity of γδ T cells against mycobacterial antigens was significantly increased by costimulatory signals generated through CD7, LFA-1, CD50 and CD69 in all groups. However, signalling through CD69 did not enhance the responsiveness of γδ lymphocytes from lepromatous patients. On the other hand, the in vitro blockade of IL-10 with a specific antibody enhanced the cell proliferation of γδ lymphocytes from lepromatous leprosy patients, whereas exogenous IL-10 had an opposite effect in most individuals studied. These results suggest the potential role of different cell membrane receptors in the regulation of γδ T cell proliferation induced by mycobacteria, as well as the possible involvement of IL-10 in this phenomenon.
most specific type: Article
issue: 3

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RDF description of Co-stimulatory signals increase the reactivity of T cells towards mycobacterial antigens - http://orbis.uaslp.mx/vivo/individual/scopus863
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date: 2026-08-24T21:51:29
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Clinical and Experimental Immunology
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publication venue for: Co-stimulatory signals increase the reactivity of T cells towards mycobacterial antigens
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type: Periodical
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