Document
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Continuant
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Respiratory Syncytial Virus-A ON1 Genotype Emergence in Central Mexico in 2009 and Evidence of Multiple Duplication Events
most specific type: Document
accesstype: All Open Access, Bronze
abstract: Background Respiratory syncytial virus (RSV) is a leading cause of respiratory infections. An RSV-A genotype (ON1) that contains a 72-nt duplication was reported in 2012 and has since extended worldwide. Methods We analyzed 345 respiratory samples obtained between 2003 and 2014 to assess the relevance of ON1 infections. Nucleotidic and deduced amino acid sequences from viruses detected in San Luis Potosí and sequences previously reported were analyzed. Results RSV ON1 was detected in 105 samples. The earliest case of ON1 infection was detected in November 2009, almost 1 year prior to detection of this virus in Canada. Amino acid sequence analysis of the duplication region showed the presence of Y273N and L274P substitutions in RSV GA2 viruses that, when combined, resulted in 4 different GXXSPSQ sequence motifs at positions 272-278. Three of these motifs were present in both the original and duplicated regions of ON1 strains. Additional signature amino acid substitutions were observed in ON1 strains that have the different sequence motifs. Conclusions ON1 strains include viruses that appear to be the result of at least 3 independent duplication events. Molecular data of strains from diverse geographical regions should help define the frequency and implications of this evolution mechanism. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
volume: 217
related by: authorship_47932
EI dscopus: 2-s2.0-85044235064
type: Continuant
most specific type: Conference Paper
type: Article
type: Entity
related by: authorship_47928
doi: 10.1093/infdis/jiy025
issue: 7
related by: authorship_47930
pmid: 29373744
has publication venue: Journal of Infectious Diseases
type: Document
type: Generically Dependent Continuant
estado: published
crisid: 7502
type: Information Content Entity
freetext keyword: gene duplication; hOPV; Human orthopneumovirus; lower respiratory tract infections; ON1 genotype; Respiratory syncytial virus; RSV amino acid sequence; amino acid substitution; Canada; Conference Paper; gene duplication; genotype; Human respiratory syncytial virus A; Mexico; molecular evolution; nonhuman; nucleotide sequence; priority journal; protein motif; virus detection; virus strain; gene duplication; genetics; genotype; human; Human respiratory syncytial virus; infant; newborn; phylogeny; preschool child; respiratory syncytial virus infection; season; virology; Child, Preschool; Evolution, Molecular; Gene Duplication; Genotype; Humans; Infant; Infant, Newborn; Mexico; Phylogeny; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Seasons
has funding vehicle: DSA/103.5-16-14532, DSA/103.5/16/14496
related by: authorship_47931
origen: scopus
related by: authorship_47929
type: Conference Paper
date time value: conference paper date 7502
type: Thing
page end: 1098
page start: 1089

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Generically Dependent Continuant
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RDF description of Respiratory Syncytial Virus-A ON1 Genotype Emergence in Central Mexico in 2009 and Evidence of Multiple Duplication Events - http://orbis.uaslp.mx/vivo/individual/scopus7501
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date: 2026-08-24T21:49:42
publisher: vivo
type: Document

DSA/103.5-16-14532, DSA/103.5/16/14496
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funding vehicle for: Respiratory Syncytial Virus-A ON1 Genotype Emergence in Central Mexico in 2009 and Evidence of Multiple Duplication Events

Article
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Information Content Entity
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Journal of Infectious Diseases
publication venue for: Respiratory Syncytial Virus-A ON1 Genotype Emergence in Central Mexico in 2009 and Evidence of Multiple Duplication Events
type: Information Content Entity
type: Journal
type: Continuant
type: Generically Dependent Continuant
type: Document
type: Collection
type: Periodical
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Conference Paper
type: Class