Document
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Environmental Health Perspectives
type: Continuant
type: Document
type: Journal
type: Information Content Entity
type: Thing
type: Generically Dependent Continuant
publication venue for: Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels
type: Collection
type: Periodical
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Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels
freetext keyword: Arsenic; Buthionine sulfoximine; Glutathione; Lipid peroxidation; Metals; N-acetylcysteine acetylcysteine; arsenic; arsenite sodium; buthionine sulfoximine; glutathione; lipid; animal experiment; concentration response; conference paper; controlled study; female; heart; kidney; lipid peroxidation; liver; nonhuman; priority journal; rat; skin; tissue distribution; tissue level; Animalia
origen: scopus
issue: SUPPL. 1
page start: 85
volume: 103
crisid: 7464
pmid: 7621808
type: Generically Dependent Continuant
chemicalscas: acetylcysteine, 616-91-1; arsenic, 7440-38-2; arsenite sodium, 13464-37-4; buthionine sulfoximine, 5072-26-4; glutathione, 70-18-8; lipid, 66455-18-3
type: Article
related by: authorship_47713
type: Document
has publication venue: Environmental Health Perspectives
related by: authorship_47714
abstract: The role of lipid peroxidation in the mechanism of arsenic toxicity was investigated in female rats pretreated with N-acetylcysteine (NAC, a glutathione [GSH] inducer) or with buthionine sulfoximine (BSO, a GSH depletor). Rats were challenged with sodium arsenite, and sacrificed 1 hr after this treatment. Results showed that arsenic decreased GSH levels and increased lipid peroxidation in liver, kidney, and heart, with a larger effect at 18.2 mg/kg than at 14.8 mg/kg for lipid peroxidation induction. In the liver of rats treated with arsenic, pretreatment with NAC increased the levels of GSH and decreased lipid peroxidation. In kidney and heart, NAC pretreatment protected the tissues against arsenic-induced depletion of GSH levels, but the same degree of protection was not found for lipid peroxidation induction. In its turn, BSO had an additive effect with arsenic in lowering the levels of GSH in the liver and kidney, but an inverse correlation between GSH levels and lipid peroxidation was found only in liver. Arsenic content in tissues of rats pretreated with NAC was lower than in rats treated only with arsenic. In rats with depleted levels of GSH (BSO-pretreated rats), a shift in arsenic tissue distribution was found, with higher levels in skin and lower levels in kidney. A clear tendency for a positive correlation between arsenic concentration and lipid peroxidation levels was found in liver, kidney, and heart.
related by: authorship_47710
most specific type: Document
most specific type: Conference Paper
related by: authorship_47712
type: Conference Paper
type: Information Content Entity
type: Entity
EI dscopus: 2-s2.0-0028933974
doi: 10.1289/ehp.95103s185
type: Continuant
type: Thing
related by: authorship_47715
date time value: conference paper date 7464
page end: 88
accesstype: All Open Access, Bronze, Green
related by: authorship_47716
estado: published

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RDF description of Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels - http://orbis.uaslp.mx/vivo/individual/scopus7463
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date: 2026-08-24T21:45:37
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