Document
type: Class

Usefulness of logistic-pharmacokinetic-pharmacodynamic analysis for rational dosing: The case of ketorolac in postoperative pain
type: Generically Dependent Continuant
most specific type: Article
type: Document
abstract: Ketorolac (KT) is a potent analgesic drug effective in the treatment of moderate to severe pain. However, the scientific basis for KT prescribing are not clear. We have previously reported the indirect relationship between plasma levels (Cp) and analgesic effect (PK/PD) of KT in patients with severe pain. Notwithstanding, the ordered categorical nature of pain relief measurement and the delay of effect with respect to analgesic plasma concentration create problems in data interpretation and inference. This paper further reviews the PK/PD results applying a logistic univariate analysis to estimate the probability distribution of: (1) time to onset; (2) duration of effect and, importantly, (3) a certain degree of pain relief as a function KT concentration in the effect compartment (Ce). In addition, both the PD and logistic results were used to generate Cp, Ce and effect-time and analgesic effect-Ce curves for several doses of KT. Simulations would indicate that 10 mg dose elicits a greater onset time and a lesser duration time of effect than obtained with the readily administered 30 mg im dose of KT (60 and 330 min respectively). Otherwise, simulated 60 and 90 mg doses do not elicit significant advantage in onset time, although duration might be increased with regard to tested 30 mg dose of KT. However, the elevated Ce reached with such doses could be associated with side effects of this drug. Therefore, neither doses higher than 30 mg im of KT nor remedication before one hour should be considered adequate in the treatment of postoperative severe pain.
related by: authorship 3447
type: Continuant
type: Information Content Entity
related by: authorship 3449
type: Article
type: Entity
volume: 41
most specific type: Document
type: Thing
has publication venue: Proceedings of the Western Pharmacology Society
e iscopus: 2-s2.0-33748204587
related by: authorship 3444
date time value: article date 721
related by: authorship 3446
estado: published
crisid: 721
related by: authorship 3445
origen: scopus
page start: 284
related by: authorship 3448

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Proceedings of the Western Pharmacology Society
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type: Generically Dependent Continuant
type: Thing
type: Information Content Entity
publication venue for: Usefulness of logistic-pharmacokinetic-pharmacodynamic analysis for rational dosing: The case of ketorolac in postoperative pain
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type: Continuant
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type: Periodical
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RDF description of Usefulness of logistic-pharmacokinetic-pharmacodynamic analysis for rational dosing: The case of ketorolac in postoperative pain - http://orbis.uaslp.mx/vivo/individual/scopus720
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date: 2026-08-25T22:11:57
publisher: vivo
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