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Gamma zein promoter; Maize; Molecular farming; Oral immunization; Seed; Vaccine; Vacuole targeting; Zea mays bacterial vaccine; virus vaccine; enterotoxigenic Escherichia coli; Escherichia coli Infections; gene expression; genetics; immunology; maize; metabolism; microbiology; plant seed; transgenic plant; Bacterial Vaccines; Enterotoxigenic Escherichia coli; Escherichia coli Infections; Gene Expression; Plants, Genetically Modified; Seeds; Viral Vaccines; Zea mays
Corn-based vaccines: current status and prospects
Main conclusion: Corn is an attractive host for vaccine production and oral delivery. The present review provides the current outlook and perspectives for this field. Among seed-crops, corn represents a key source of biomass for food, fuel production, and other applications. Since the beginning of the development of plant-based vaccines, corn was explored for the production and delivery of vaccines. About a dozen of pathogens have been studied under this technology with distinct degrees of development. A vaccine prototype against enterotoxigenic Escherichia coli was evaluated in a phase I clinical trial and several candidates targeting bacterial and viral diseases are under preclinical evaluation. The present review provides an updated outlook on this topic highlighting the employed expression strategies; perspectives for the field are also provided. © 2017, Springer-Verlag Berlin Heidelberg.
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