Bacillus subtilis comes of age as a vaccine production host and delivery vehicle
page end: 1148
has publication venue: Expert Review of Vaccines
type: Article
crisid: 7056
type: Generically Dependent Continuant
origen: scopus
type: Review
related by: authorship_45716
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 151818, 225924, CB-2010-01, INFR-2014-01
volume: 14
type: Document
chemicalscas: Adjuvants, Immunologic; Bacterial Vaccines; Drug Carriers; Vaccines
most specific type: Document
pmid: 26028252
most specific type: Review
abstract: Bacillus subtilis is a vaccine production host and delivery vector with several advantages such as a low production cost, straightforward administration as it is safe for human consumption and the production of spores exerting adjuvant effects. This review summarizes the expression approaches and provides an updated outlook of how a myriad of pathogens have been targeted under this technology. Furthermore, by reviewing the literature, several promising candidates in terms of immunogenic and immunoprotective potential have been identified. The immune profiles achieved comprise either humoral or cellular responses, which reflect versatility for application in the fight of distinct pathologies that demand specific polarization on the immune responses. Some perspectives for this field are also envisioned. © 2015 Informa UK, Ltd.
related by: authorship_45715
has funding vehicle: INFR-2014-01-225843
type: Information Content Entity
e iscopus: 2-s2.0-84937129636
issue: 8
page start: 1135
type: Thing
type: Entity
date time value: review date 7056
freetext keyword: cytotoxic lymphocyte; delivery vehicle; intranasal immunization; low cost vaccine; mucosal vaccines; oral immunization; particulate antigen; spore; sublingual immunization bacterial vaccine; subunit vaccine; bacterial vaccine; drug carrier; immunological adjuvant; vaccine; antibody production; antibody response; antigen expression; antigen presentation; antigen presenting cell; Bacillus subtilis; bacterial spore; cellular immunity; drug delivery system; drug design; human; humoral immunity; immunogenicity; nonhuman; polarization; priority journal; Review; spore germination; thermostability; vaccination; vaccine production; animal; Bacillus subtilis; drug delivery system; genetics; immunology; isolation and purification; metabolism; Adjuvants, Immunologic; Animals; Bacillus subtilis; Bacterial Vaccines; Drug Carriers; Drug Delivery Systems; Humans; Spores, Bacterial; Vaccines
doi: 10.1586/14760584.2015.1051469
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estado: published

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RDF description of Bacillus subtilis comes of age as a vaccine production host and delivery vehicle - http://orbis.uaslp.mx/vivo/individual/scopus7055
rights: termsOfUse
date: 2026-08-27T12:37:51
publisher: vivo
type: Document

Article
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Consejo Nacional de Ciencia y Tecnología, CONACYT: 151818, 225924, CB-2010-01, INFR-2014-01
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INFR-2014-01-225843
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funding vehicle for: Bacillus subtilis comes of age as a vaccine production host and delivery vehicle

Expert Review of Vaccines
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