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Pharmacy and Pharmacology Communications
Generically Dependent Continuant
The effect of non-steroidal anti-inflammatory drugs on oral caffeine bioavailability was studied in male Wistar rats. Caffeine (32 mg kg-1) was given by gavage either alone or combined with paracetamol (316 mg kg-1), tolmetin (3 mg kg-1), ketorolac (1.8 mg kg-1) and ibuprofen (100 mg kg-1). Blood samples were drawn at selected times and caffeine concentration in whole blood was determined by high-performance liquid chromatography. Caffeine bioavailability was not significantly modified by co-administration with any of these non-steroidal anti-inflammatory drugs (NSAIDs). Since caffeine bioavailability is not increased by NSAIDs, and caffeine does not increase NSAID bioavailability, it is concluded that caffeine potentiation of the analgesic effect of NSAIDs is not due to a pharmacokinetic interaction.
cilag, Mexico; hoffmann la roche, Mexico; sigma, United States
Caffeine bioavailability after administration with and without non-steroidal anti-inflammatory drugs in rats
caffeine; ibuprofen; ketorolac; nonsteroid antiinflammatory agent; paracetamol; tolmetin; animal experiment; article; controlled study; drug bioavailability; drug blood level; drug potentiation; high performance liquid chromatography; male; nonhuman; oral drug administration; rat
RDF description of Caffeine bioavailability after administration with and without non-steroidal anti-inflammatory drugs in rats - http://orbis.uaslp.mx/vivo/individual/scopus686
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