Document
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Pharmacy and Pharmacology Communications
publication venue for: Caffeine bioavailability after administration with and without non-steroidal anti-inflammatory drugs in rats
type: Document
type: Journal
type: Collection
type: Generically Dependent Continuant
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type: Information Content Entity
type: Periodical

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Caffeine bioavailability after administration with and without non-steroidal anti-inflammatory drugs in rats
e iscopus: 2-s2.0-0344972889
type: Entity
chemicalscas: caffeine, 30388-07-9, 58-08-2; ibuprofen, 15687-27-1; ketorolac, 74103-06-3; paracetamol, 103-90-2; tolmetin, 26171-23-3, 35711-34-3
issue: 9
estado: published
most specific type: Article
date time value: article date 687
most specific type: Document
related by: authorship 3282
volume: 4
type: Article
abstract: The effect of non-steroidal anti-inflammatory drugs on oral caffeine bioavailability was studied in male Wistar rats. Caffeine (32 mg kg-1) was given by gavage either alone or combined with paracetamol (316 mg kg-1), tolmetin (3 mg kg-1), ketorolac (1.8 mg kg-1) and ibuprofen (100 mg kg-1). Blood samples were drawn at selected times and caffeine concentration in whole blood was determined by high-performance liquid chromatography. Caffeine bioavailability was not significantly modified by co-administration with any of these non-steroidal anti-inflammatory drugs (NSAIDs). Since caffeine bioavailability is not increased by NSAIDs, and caffeine does not increase NSAID bioavailability, it is concluded that caffeine potentiation of the analgesic effect of NSAIDs is not due to a pharmacokinetic interaction.
related by: authorship 3281
type: Continuant
page end: 453
crisid: 687
type: Document
manufactures: cilag, Mexico; hoffmann la roche, Mexico; sigma, United States
page start: 451
origen: scopus
type: Generically Dependent Continuant
type: Information Content Entity
freetext keyword: caffeine; ibuprofen; ketorolac; nonsteroid antiinflammatory agent; paracetamol; tolmetin; animal experiment; article; controlled study; drug bioavailability; drug blood level; drug potentiation; high performance liquid chromatography; male; nonhuman; oral drug administration; rat
related by: authorship 3283
type: Thing
has publication venue: Pharmacy and Pharmacology Communications

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date: 2026-08-28T02:05:47
publisher: vivo
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