Domestic Animal Endocrinology
publication venue for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep
type: Entity
type: Journal
type: Periodical
type: Continuant
type: Information Content Entity
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type: Document

Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep
related by: authorship_44229
type: Document
type: Generically Dependent Continuant
has funding vehicle: National Institute of Food and Agriculture, NIFA
has funding vehicle: R01ES027863
has funding vehicle: Michigan State University, MSU
has funding vehicle: College of Agriculture and Natural Resources, Michigan State University, CANR
related by: authorship_44232
abstract: Changes in maternal nutrition during pregnancy can result in profound effects on placental function and fetal development. Although the preconceptional period holds the potential to reprogram embryonic and placental development, little is known regarding the effects of premating nutritional manipulation on placental function and fetal and postnatal offspring growth. To test this, Polypay-Dorset sheep (n = 99) were assigned to 1 of 3 nutritional treatments (n = 33/treatment) receiving 50%25 (UN: undernutrition), 100%25 (C: control), or 200%25 (ON: overnutrition) of maintenance energy requirements for 21 d before mating during April–May (increasing photoperiod). Thereafter, diets were the same across groups. We evaluated maternal reproductive variables and maternal and offspring weight and body mass index through weaning. Maternal plasma was collected through pregnancy until postnatal day 1 to assay pregnancy-associated glycoproteins (PAGs) and progesterone. Fertility rate was similar among treatments, but ON females had a higher reproductive rate (UN: 82%25; C: 100%25, ON: 145%25). When correcting by total birth weight, twin pregnancies had lower PAGs and progesterone versus singleton pregnancies (P < 0.001). At birth, UN lambs were heavier than C lambs regardless of birth type (P < 0.01). Growth velocity, daily gain, and weaning weight were similar, but UN and ON females grew faster and were heavier at weaning versus C females. We demonstrated that a 3-wk preconceptional maternal undernutrition or overnutrition, when correcting by total birth weight, results in lower endocrine capacity in twin pregnancies. Preconceptional maternal undernutrition and overnutrition increased postnatal female lamb growth, suggestive of reprogramming of pathways regulating growth before conception. This highlights how preconceptional nutrition can result in marked sex-specific differences. © 2020 Elsevier Inc.
type: Article
type: Continuant
has funding vehicle: U.S. Department of Agriculture, USDA
has funding vehicle: National Institutes of Health, NIH
crisid: 6747
origen: scopus
type: Information Content Entity
most specific type: Document
related by: authorship_44227
related by: authorship_44228
volume: 74
has publication venue: Domestic Animal Endocrinology
pmid: 33160155
related by: authorship_44231
estado: published
most specific type: Article
has funding vehicle: Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, INIFAP
has funding vehicle: Midwestern State University, MSU
related by: authorship_44230
e iscopus: 2-s2.0-85095713231
artnum: 106577
date time value: article date 6747
type: Thing
chemicalscas: progesterone, 57-83-0
doi: 10.1016/j.domaniend.2020.106577
has funding vehicle: National Institute of Environmental Health Sciences, NIEHS
type: Entity
has funding vehicle: Michigan Alliance for Animal Agriculture, M-AAA
has funding vehicle: College of Agriculture Science and Natural Resources, Institute of Agriculture and Natural Resources, CASNR
freetext keyword: Birth weight; Prebreeding diet; Pregnancy-associated glycoproteins; Progesterone placenta protein; pregnancy associated protein; progesterone; animal tissue; Article; birth weight; body constitution; body mass; body weight; body weight change; body weight gain; body weight loss; breeding; controlled study; endocrine function; female; fertility; fetus; fetus growth; lamb; male; malnutrition; maternal nutrition; maternal plasma; nonhuman; overnutrition; placenta function; pregnancy; progeny; subcutaneous fat; twin pregnancy; weaning

National Institute of Environmental Health Sciences, NIEHS
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type: BFO_0000020
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funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

Entity
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Generically Dependent Continuant
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U.S. Department of Agriculture, USDA
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type: BFO_0000020
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type: Grant
type: Continuant
funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

RDF description of Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep - http://orbis.uaslp.mx/vivo/individual/scopus6746
rights: termsOfUse
date: 2026-08-26T10:44:48
publisher: vivo
type: Document

Michigan Alliance for Animal Agriculture, M-AAA
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type: BFO_0000020
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type: Thing
type: Grant
type: Continuant
funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

Article
type: Class

National Institute of Food and Agriculture, NIFA
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type: BFO_0000020
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type: Grant
type: Continuant
funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

College of Agriculture Science and Natural Resources, Institute of Agriculture and Natural Resources, CASNR
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type: BFO_0000020
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funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

Michigan State University, MSU
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type: BFO_0000020
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funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

Document
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R01ES027863
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type: BFO_0000020
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type: Grant
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funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

Continuant
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Information Content Entity
type: Class

Midwestern State University, MSU
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

National Institutes of Health, NIH
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type: BFO_0000020
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type: Grant
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funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

College of Agriculture and Natural Resources, Michigan State University, CANR
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep

Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, INIFAP
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep