Document
type: Class

Effect of gene-environment interaction (arsenic exposure - PON1 Q192R polymorphism) on cardiovascular disease biomarkers in Mexican population
type: Article
related by: authorship_44205
type: Document
type: Thing
type: Generically Dependent Continuant
related by: authorship_44200
pmid: 33164855
origen: scopus
tradenames: Eon Microplate, Biotek, United States; Lyphochek, Biorad, United States; model Analyst 100, Perkin Elmer, United States; StepOne, Applied Biosystems, United States; TaqMan Universal PCR Master Mix, Applied Biosystems, United States
related by: authorship_44203
type: Continuant
artnum: 103519
related by: authorship_44204
crisid: 6742
has funding vehicle: Secretaría de Educación Pública, SEP
type: Information Content Entity
most specific type: Document
chemicalscas: arsenic, 7440-38-2; cholesterol, 57-88-5; creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; n(g),n(g) dimethylarginine, 30315-93-6
doi: 10.1016/j.etap.2020.103519
e iscopus: 2-s2.0-85096234974
has publication venue: Environmental Toxicology and Pharmacology
manufactures: Applied Biosystems, United States; Biorad, United States; Biotek, United States; Enzo Life Sciences, United States; Perkin Elmer, United States; Promega, United States
related by: authorship_44201
type: Entity
related by: authorship_44202
volume: 81
most specific type: Article
estado: published
freetext keyword: ADMA; Arsenic; FABP4; Gene-environment (GxE) interaction; miRNAs; Paraoxonase 1 arsenic; aryldialkylphosphatase 1; cholesterol; creatinine; fatty acid binding protein 4; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; microRNA; microRNA 155; n(g),n(g) dimethylarginine; triacylglycerol; adult; allele; Article; body mass; cardiovascular disease; cholesterol blood level; controlled study; creatinine urine level; diastolic blood pressure; disease association; disease marker; female; gender; gene frequency; gene function; genotype; genotype environment interaction; heterozygote; human; Mexican; obesity; PON1 gene; priority journal; protein blood level; real time polymerase chain reaction; systolic blood pressure; triacylglycerol blood level; urine level
abstract: Cardiovascular diseases (CVDs) are the primary cause of death worldwide. However, little is known about how the interaction between risk factors affects CVDs. Therefore, the aim of this study was to evaluate the effect of the gene-environment interaction (arsenic exposure x PON1 Q192R polymorphism) on serum levels of CVDs biomarkers in Mexican women. Urinary arsenic levels (UAs) ranged from 5.50–145 μg/g creatinine. The allele frequency was 0.38 and 0.62 for the Q and R alleles, respectively. Moreover, significant associations (p<0.05) were detected between UAs and CVDs biomarkers (ADMA, FABP4, and miR-155). Comparable data were found when CVDs biomarkers were evaluated through PON1 genotype, significant (p<0.05) higher serum concentrations of CVDs biomarkers were identified in R allele carriers compared to levels found in Q allele carriers. Besides, a gene-environment interaction was documented. The results of this study we believe should be of significant interest to regulatory authorities worldwide. © 2020 Elsevier B.V.
date time value: article date 6742

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individual
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date: 2026-08-24T21:49:53
publisher: vivo
type: Document
label: RDF description of Effect of gene-environment interaction (arsenic exposure - PON1 Q192R polymorphism) on cardiovascular disease biomarkers in Mexican population - http://orbis.uaslp.mx/vivo/individual/scopus6741

Article
type: Class

Secretaría de Educación Pública, SEP
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Effect of gene-environment interaction (arsenic exposure - PON1 Q192R polymorphism) on cardiovascular disease biomarkers in Mexican population

Environmental Toxicology and Pharmacology
type: Collection
type: Information Content Entity
type: Continuant
type: Entity
type: Thing
type: Document
type: Journal
type: Periodical
publication venue for: Effect of gene-environment interaction (arsenic exposure - PON1 Q192R polymorphism) on cardiovascular disease biomarkers in Mexican population
type: Generically Dependent Continuant

Information Content Entity
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