Document
type: Class

Consejo Nacional de Ciencia y Tecnología, CONACYT: CB-256637
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: MDM2 regulates RB levels during genotoxic stress

MDM2 regulates RB levels during genotoxic stress
related by: authorship_44051
type: Information Content Entity
related by: authorship_44054
type: Thing
most specific type: Document
related by: authorship_44053
freetext keyword: cell cycle; MDM2; protein translation; RB; RB mRNA
origen: scopus
type: Article
estado: published
volume: 22
pmid: 33185004
most specific type: Article
issue: 1
related by: authorship_44055
type: Entity
doi: 10.15252/embr.202050615
type: Document
type: Generically Dependent Continuant
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: CB-256637
e iscopus: 2-s2.0-85096798093
type: Continuant
abstract: The retinoblastoma tumour suppressor protein (RB) regulates a number of diverse cellular functions including differentiation, angiogenesis, chromatin remodelling, senescence and apoptosis. The best-characterised function of RB is cell cycle regulation, and it has been considered a phosphoprotein regulated by cyclin-dependent kinases. In its hypophosphorylated form, RB binds the transcription factor E2F1, arresting the cell cycle in the G1 phase. Here, we show that MDM2 controls the cell cycle through synthesis and degradation of RB protein in a cell cycle condition-dependent fashion. MDM2 induces G1 cell cycle arrest by enhancing the translation of the RB mRNA under genotoxic stress. Translation requires direct interaction between the RB mRNA and the MDM2 protein that accompanies the RB mRNA to the polysomes. However, MDM2 ubiquitinates and degrades RB protein at the G2/M phase under genotoxic stress. The ATM phosphomimetic mutant MDM2(S395D) corroborates that the effect on the RB levels is dependent on the DNA damage. These results provide the basis of a dual regulatory mechanism by which MDM2 controls cell cycle progression during DNA damage. © 2020 The Authors
crisid: 6723
artnum: e50615
related by: authorship_44052
date time value: article date 6723
has publication venue: EMBO Reports

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Generically Dependent Continuant
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RDF description of MDM2 regulates RB levels during genotoxic stress - http://orbis.uaslp.mx/vivo/individual/scopus6722
rights: termsOfUse
date: 2026-08-24T04:54:27
publisher: vivo
type: Document

Article
type: Class

Information Content Entity
type: Class

EMBO Reports
type: Continuant
type: Information Content Entity
type: Document
type: Journal
type: Collection
type: Generically Dependent Continuant
type: Thing
type: Entity
type: Periodical
publication venue for: MDM2 regulates RB levels during genotoxic stress