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RDF description of Synthesis of 1,4-Biphenyl-triazole Derivatives as Possible 17β-HSD1 Inhibitors: An in Silico Study - http://orbis.uaslp.mx/vivo/individual/scopus6536
rights: termsOfUse
date: 2026-08-28T03:00:12
publisher: vivo
type: Document

Article
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ACS Omega
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publication venue for: Synthesis of 1,4-Biphenyl-triazole Derivatives as Possible 17β-HSD1 Inhibitors: An in Silico Study
type: Generically Dependent Continuant

Synthesis of 1,4-Biphenyl-triazole Derivatives as Possible 17β-HSD1 Inhibitors: An in Silico Study
origen: scopus
accesstype: All Open Access, Bronze, Green
most specific type: Document
type: Thing
page start: 14061
type: Document
type: Entity
type: Continuant
related by: authorship_42699
related by: authorship_42698
page end: 14068
related by: authorship_42694
type: Article
date time value: article date 6537
type: Information Content Entity
crisid: 6537
related by: authorship_42696
abstract: Triazoles occupy an important position in medicinal chemistry because of their various biological activities. The structural features of 1,2,3-triazoles enable them to act as a bioisostere of different functional groups such as amide, ester, carboxylic acid, and heterocycle, being capable of forming hydrogen bonds and π-πinteractions or coordinate metal ions with biological targets. In this work, the synthesis of 1,2,3-triazole derivatives via copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is reported. Overexpression of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is often found in breast cancer cells. Molecular similarity and docking analysis were used to evaluate the potential inhibitory activity of 1,2,3-triazoles synthesized over 17β-HSD1 for the treatment of mammary tumors. Our in silico analysis shows that compounds 4c, 4d, 4f, 4g, and 4j are good molecular scaffold candidates as 17β-HSD1 inhibitors. Copyright © 2020 American Chemical Society.
related by: authorship_42697
type: Generically Dependent Continuant
volume: 5
related by: authorship_42693
estado: published
issue: 23
doi: 10.1021/acsomega.0c01519
has publication venue: ACS Omega
related by: authorship_42695
most specific type: Article
e iscopus: 2-s2.0-85086251633