Document
type: Class

Continuant
type: Class

Entity
type: Class

Generically Dependent Continuant
type: Class

individual
rights: termsOfUse
date: 2026-08-24T21:51:01
publisher: vivo
type: Document
label: RDF description of Perinuclear lamin a and nucleoplasmic lamin B2 characterize two types of hippocampal neurons through Alzheimer’s disease progression - http://orbis.uaslp.mx/vivo/individual/scopus6414

Article
type: Class

International Journal of Molecular Sciences
type: Thing
type: Document
type: Journal
type: Periodical
publication venue for: Perinuclear lamin a and nucleoplasmic lamin B2 characterize two types of hippocampal neurons through Alzheimer’s disease progression
type: Information Content Entity
type: Continuant
type: Collection
type: Entity
type: Generically Dependent Continuant

Information Content Entity
type: Class

Perinuclear lamin a and nucleoplasmic lamin B2 characterize two types of hippocampal neurons through Alzheimer’s disease progression
related by: authorship_41704
type: Generically Dependent Continuant
related by: authorship_41705
type: Document
type: Article
abstract: Background. Recent reports point to a nuclear origin of Alzheimer’s disease (AD). Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle. This aberrant cell cycle re-entry involves chromatin modifications where nuclear Tau and the nuclear lamin are involved. The purpose of this work was to elucidate their participation in the nuclear pathological transformation of neurons at early AD. Methodology. The study was performed in hippocampal paraffin embedded sections of adult, senile, and AD brains at I-VI Braak stages. We analyzed phospho-Tau, lamins A, B1, B2, and C, nucleophosmin (B23) and the epigenetic marker H4K20me3 by immunohistochemistry. Results. Two neuronal populations were found across AD stages, one is characterized by a significant increase of Lamin A expression, reinforced perinuclear Lamin B2, elevated expression of H4K20me3 and nuclear Tau loss, while neurons with nucleoplasmic Lamin B2 constitute a second population. Conclusions. The abnormal cell cycle reentry in early AD implies a fundamental neuronal transformation. This implies the reorganization of the nucleo-cytoskeleton through the expression of the highly regulated Lamin A, heterochromatin repression and building of toxic neuronal tangles. This work demonstrates that nuclear Tau and lamin modifications in hippocampal neurons are crucial events in age-related neurodegeneration. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
has publication venue: International Journal of Molecular Sciences
related by: authorship_41708
crisid: 6415
related by: authorship_41710
type: Information Content Entity
pmid: 32155994
related by: authorship_41709
estado: published
type: Entity
most specific type: Document
related by: authorship_41703
type: Continuant
artnum: 1841
most specific type: Article
volume: 21
issue: 5
related by: authorship_41706
origen: scopus
freetext keyword: Alzheimer’s disease; Cell-cycle; Heterochromatin; Hippocampus; Lamin A; Lamin B2; Neurofibrillary tangles; Tau protein lamin A; lamin B; lamin B1; lamin B2; lamin C; nucleophosmin; tau protein; unclassified drug; lamin A; lamin B; lamin B2; tau protein; adult; aged; Alzheimer disease; Article; brain nerve cell; cell cycle; cell population; cell transformation; cellular, subcellular and molecular biological phenomena and functions; controlled study; cytoskeleton; disease exacerbation; heterochromatin; heterochromatin repression; hippocampal CA1 region; hippocampal CA3 region; hippocampal neuron; human; human cell; human tissue; immunohistochemistry; neuronal tangle; protein depletion; protein expression; protein function; protein localization; protein modification; protein phosphorylation; Alzheimer disease; cell aging; cytology; disease exacerbation; genetics; hippocampus; metabolism; nerve cell; nuclear lamina; pathology; physiology; Alzheimer Disease; Cell Cycle; Cellular Senescence; Disease Progression; Hippocampus; Humans; Lamin Type A; Lamin Type B; Neurons; Nuclear Lamina; tau Proteins
related by: authorship_41707
type: Thing
date time value: article date 6415
doi: 10.3390/ijms21051841
accesstype: All Open Access, Gold, Green
chemicalscas: nucleophosmin, 117896-08-9; lamin B2; Lamin Type A; Lamin Type B; tau Proteins
e iscopus: 2-s2.0-85081197660