35456
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funding vehicle for: The urinary metabolome of healthy newborns

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RDF description of The urinary metabolome of healthy newborns - http://orbis.uaslp.mx/vivo/individual/scopus6385
rights: termsOfUse
date: 2026-08-24T21:51:13
publisher: vivo
type: Document

Article
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Metabolites
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publication venue for: The urinary metabolome of healthy newborns
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type: Document
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Consejo Nacional de Ciencia y Tecnología, CONACYT: 290239
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type: BFO_0000020
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funding vehicle for: The urinary metabolome of healthy newborns

Document
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Genome Canada
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funding vehicle for: The urinary metabolome of healthy newborns

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The urinary metabolome of healthy newborns
related by: authorship_41526
has funding vehicle: 35456
accesstype: All Open Access, Gold, Green
type: Article
type: Information Content Entity
related by: authorship_41530
abstract: The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate’s metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
crisid: 6386
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chemicalscas: 6 n,n' dimethylarginine, 30344-00-4; acetylcarnitine, 14992-62-2; DOPA, 587-45-1; histamine, 51-45-6, 56-92-8, 93443-21-1; methionine sulfoxide, 454-41-1; n(g),n(g) dimethylarginine, 30315-93-6; n1,n12 diethylspermine, 61345-84-4; propionylcarnitine, 17298-37-2, 119793-66-7; putrescine, 110-60-1, 333-93-7; salicyluric acid, 487-54-7; serotonin, 50-67-9; spermidine, 124-20-9, 334-50-9; spermine, 306-67-2, 71-44-3; trimethylamine oxide, 1184-78-7
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 290239
has funding vehicle: Genome Canada
has publication venue: Metabolites
related by: authorship_41529
type: Thing
related by: authorship_41528
related by: authorship_41532
related by: authorship_41534
issue: 4
related by: authorship_41539
doi: 10.3390/metabo10040165
most specific type: Document
related by: authorship_41540
related by: authorship_41531
volume: 10
related by: authorship_41533
artnum: 165
related by: authorship_41527
related by: authorship_41538
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most specific type: Article
type: Generically Dependent Continuant
related by: authorship_41536
origen: scopus
date time value: article date 6386
estado: published
freetext keyword: Inborn errors of metabolism; Metabolites; Newborn; Reference values; Tandem mass spectrometry 6 n,n' dimethylarginine; acetylcarnitine; decanoylcarnitine; decenoylcarnitine; DOPA; drug metabolite; glutaconylcarnitine; glutaryl carnitine; hexanoylcarnitine; hexenoylcarnitine; histamine; hydroxybutyryl carnitine; hydroxyvalerylcarnitine; methionine sulfoxide; methylglutarylcarnitine; n(g),n(g) dimethylarginine; n1,n12 diethylspermine; nonaylcarnitine; octadecadienylcarnitine; octanoyl carnitine; pimelylcarnitine; propionylcarnitine; putrescine; salicyluric acid; serotonin; spermidine; spermine; tiglylcarnitine; trimethylamine oxide; unclassified drug; unindexed drug; Article; biochemical analysis; birth weight; body mass; experimental study; female; gestational age; health status; high performance liquid chromatography; human; human experiment; male; mass fragmentography; metabolome; metabolomics; n acetylornithine; newborn; normal human; proton nuclear magnetic resonance; sex difference; tandem mass spectrometry; urinalysis

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