Generically Dependent Continuant
RDF description of The urinary metabolome of healthy newborns - http://orbis.uaslp.mx/vivo/individual/scopus6385
Article
Consejo Nacional de Ciencia y Tecnología, CONACYT: 290239
Document
The urinary metabolome of healthy newborns
The knowledge of normal metabolite values for neonates is key to establishing robust cut-off values to diagnose diseases, to predict the occurrence of new diseases, to monitor a neonate’s metabolism, or to assess their general health status. For full term-newborns, many reference biochemical values are available for blood, serum, plasma and cerebrospinal fluid. However, there is a surprising lack of information about normal urine concentration values for a large number of important metabolites in neonates. In the present work, we used targeted tandem mass spectrometry (MS/MS)-based metabolomic assays to identify and quantify 136 metabolites of biomedical interest in the urine from 48 healthy, full-term term neonates, collected in the first 24 h of life. In addition to this experimental study, we performed a literature review (covering the past eight years and over 500 papers) to update the references values in the Human Metabolome Database/Urine Metabolome Database (HMDB/UMDB). Notably, 86 of the experimentally measured urinary metabolites are being reported in neonates/infants for the first time and another 20 metabolites are being reported in human urine for the first time ever. Sex differences were found for 15 metabolites. The literature review allowed us to identify another 78 urinary metabolites with concentration data. As a result, reference concentration values and ranges for 378 neonatal urinary metabolites are now publicly accessible via the HMDB. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Inborn errors of metabolism; Metabolites; Newborn; Reference values; Tandem mass spectrometry 6 n,n' dimethylarginine; acetylcarnitine; decanoylcarnitine; decenoylcarnitine; DOPA; drug metabolite; glutaconylcarnitine; glutaryl carnitine; hexanoylcarnitine; hexenoylcarnitine; histamine; hydroxybutyryl carnitine; hydroxyvalerylcarnitine; methionine sulfoxide; methylglutarylcarnitine; n(g),n(g) dimethylarginine; n1,n12 diethylspermine; nonaylcarnitine; octadecadienylcarnitine; octanoyl carnitine; pimelylcarnitine; propionylcarnitine; putrescine; salicyluric acid; serotonin; spermidine; spermine; tiglylcarnitine; trimethylamine oxide; unclassified drug; unindexed drug; Article; biochemical analysis; birth weight; body mass; experimental study; female; gestational age; health status; high performance liquid chromatography; human; human experiment; male; mass fragmentography; metabolome; metabolomics; n acetylornithine; newborn; normal human; proton nuclear magnetic resonance; sex difference; tandem mass spectrometry; urinalysis
Information Content Entity