Document
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Continuant
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Entity
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Generically Dependent Continuant
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individual
rights: termsOfUse
date: 2026-08-25T01:05:02
publisher: vivo
type: Document
label: RDF description of Gold nanoparticles (AuNP) exert immunostimulatory and protective effects in shrimp (Litopenaeus vannamei) against Vibrio parahaemolyticus - http://orbis.uaslp.mx/vivo/individual/scopus6205

Article
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Information Content Entity
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Fish and Shellfish Immunology
type: Collection
type: Entity
type: Generically Dependent Continuant
type: Document
type: Thing
type: Journal
publication venue for: Gold nanoparticles (AuNP) exert immunostimulatory and protective effects in shrimp (Litopenaeus vannamei) against Vibrio parahaemolyticus
type: Continuant
type: Information Content Entity
type: Periodical

Gold nanoparticles (AuNP) exert immunostimulatory and protective effects in shrimp (Litopenaeus vannamei) against Vibrio parahaemolyticus
estado: published
related by: authorship_40155
related by: authorship_40151
related by: authorship_40154
origen: scopus
volume: 84
type: Entity
e iscopus: 2-s2.0-85055658924
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: FC-2016/2820, INFR-2014-01/225924, PDCPN2014-01/248033
type: Information Content Entity
related by: authorship_40150
page end: 767
page start: 756
freetext keyword: Acute hepatopancreatic necrosis disease; AHPND; Crustacean; Diseases; Immune response; Immunostimulants; Metallic nanoparticles catalase; gold nanoparticle; myeloperoxidase; peroxidase; superoxide dismutase; toll like receptor 3; gold; immunological adjuvant; metal nanoparticle; protective agent; animal cell; animal experiment; animal model; animal tissue; Article; bacterial strain; blood cell; cell count; cellular immunity; controlled study; drug distribution; enzyme activity; gene; gene expression; hemolymph; hepatopancreas; histopathology; humoral immunity; immunostimulation; in vivo study; Litopenaeus vannamei; liver necrosis; nonhuman; priority journal; propo gene; single drug dose; upregulation; Vibrio parahaemolyticus; Vibrio parahaemolyticus infection; zeta potential; animal; drug effect; immunology; Penaeidae; physiology; tissue distribution; Vibrio parahaemolyticus; Adjuvants, Immunologic; Animals; Gold; Metal Nanoparticles; Penaeidae; Protective Agents; Tissue Distribution; Vibrio parahaemolyticus
related by: authorship_40149
date time value: article date 6206
type: Continuant
has publication venue: Fish and Shellfish Immunology
related by: authorship_40156
type: Generically Dependent Continuant
crisid: 6206
related by: authorship_40148
most specific type: Document
chemicalscas: catalase, 9001-05-2; myeloperoxidase; peroxidase, 9003-99-0; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; gold, 7440-57-5; Adjuvants, Immunologic; Gold; Protective Agents
most specific type: Article
doi: 10.1016/j.fsi.2018.10.056
related by: authorship_40153
type: Thing
pmid: 30368027
type: Document
abstract: Gold nanoparticles (AuNP) stimulate immune responses in mammals but they have not been tested in species of relevance in aquaculture. In this study the immunostimulant and protective potential of orally administered AuNP against V. parahaemolyticus, the causative agent of Acute Hepatopancreatic Necrosis Disease, was determined in shrimp. Synthetized AuNP (18.57 ± 4.37 nm) were moderately dispersed with a negative ζ potential of −10.3 ± 0.208 mV (pH = 7). AuNP were administered (single dose) at 0.2, 2, and 20 μg/g feed in shrimp. Hemolymph samples were withdrawn daily for 6 days. Hemolymph or hemocytes were used to determine total hemocyte counts, immune-related enzymatic activities, and expression of immune-relevant genes. Hepatopancreas was sampled for the analysis of AuNP biodistribution and histological examination. Survival was recorded daily. No mortality or toxicity signs in hepatopancreas were found. AuNP were detected in hepatopancreas. Early (24–48 h) immunostimulation was mainly related to immune gene up-regulation. Upon a challenge with V. parahaemolyticus, survival was higher (80%25) and histopathological damages were lower in shrimp treated with the 2 μg/g dose when compared to the control. Therefore orally administered AuNP are proposed as immunostimulants that protect shrimp against V. parahaemolyticus infection. © 2018 Elsevier Ltd
related by: authorship_40152
type: Article

Consejo Nacional de Ciencia y Tecnología, CONACYT: FC-2016/2820, INFR-2014-01/225924, PDCPN2014-01/248033
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type: BFO_0000020
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type: Grant
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funding vehicle for: Gold nanoparticles (AuNP) exert immunostimulatory and protective effects in shrimp (Litopenaeus vannamei) against Vibrio parahaemolyticus