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Consejo Nacional de Ciencia y Tecnología, CONACYT: 695756
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type: BFO_0000020
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funding vehicle for: Hydrogel-embedded gold nanorods activated by plasmonic photothermy with potent antimicrobial activity

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Hydrogel-embedded gold nanorods activated by plasmonic photothermy with potent antimicrobial activity
type: Document
abstract: Plasmonic photothermal therapy (PPTT) has been used as an alternative to chemotherapy for the elimination of resistant microorganisms; however, its in situ evaluation has not been well studied. In the present study, we assessed the antimicrobial activity of a chitosan-based hydrogel embedded with gold nanorods (Ch/AuNRs) using a low power infrared diode laser. The antibacterial activity was measured in both Gram-positive and –negative strains, including clinical isolates of multidrug-resistant pathogens. The cytotoxic effect, cellular proliferation, and the expression of the pro-inflammatory (IL-6 and TNF-α) and anti-inflammatory (IL-10) cytokines were quantified in a murine model of macrophages. Results showed a potent antimicrobial activity of the Ch/AuNRs with MICs ≤4 μg/mL, very low cytotoxicity with cell viability above 80%25, and the macrophage proliferation was not affected for a period of 48 h. These results suggest that our Ch/AuNR-embedded hydrogel could be an option to locally control chronic nosocomial infections using PPTT. © 2019 Elsevier Inc.
freetext keyword: Antibacterial; Antifungal; Chitosan; Cytotoxicity; Gold nanorod; Inflammation; Multidrug resistant; Photothermal therapy Cell proliferation; Chemotherapy; Chitosan; Cytotoxicity; Gold; Hydrogels; Macrophages; Nanorods; Petroleum reservoir evaluation; Plasmonics; Anti-fungal; Antibacterial; Gold nanorod; Inflammation; Multidrug resistants; Photothermal therapy; Microorganisms; amikacin; ceftazidime; ceftizoxime; ciprofloxacin; clindamycin; ertapenem; erythromycin; gold nanorod; interleukin 10; interleukin 6; oxacillin; penicillin derivative; piperacillin plus tazobactam; tobramycin; tumor necrosis factor; antifungal agent; antiinfective agent; broxuridine; chitosan; gold; nanotube; Acinetobacter baumannii; antifungal activity; antimicrobial activity; Article; bacterial strain; broth dilution; Candida albicans; cell proliferation; cell viability; controlled study; Cryptococcus neoformans; disk diffusion; hydrogel; immune response; Klebsiella pneumoniae; methicillin resistant Staphylococcus aureus; minimum bactericidal concentration; minimum fungicidal concentration; nonhuman; photothermal therapy; plasmonic photothermal therapy; protein expression; Pseudomonas aeruginosa; RAW 264.7 cell line; scanning electron microscopy; Staphylococcus aureus; Staphylococcus epidermidis; transmission electron microscopy; Trichophyton mentagrophytes; ultraviolet spectrophotometry; X ray spectroscopy; animal; cell death; chemistry; drug effect; hydrogel; inflammation; metabolism; microbial sensitivity test; mouse; pathology; pharmacology; phototherapy; thermotherapy; ultrastructure; Animals; Anti-Infective Agents; Antifungal Agents; Bromodeoxyuridine; Cell Death; Cell Proliferation; Chitosan; Gold; Hydrogels; Hyperthermia, Induced; Inflammation; Mice; Microbial Sensitivity Tests; Nanotubes; Phototherapy; RAW 264.7 Cells
related by: authorship_39948
most specific type: Article
type: Generically Dependent Continuant
artnum: 102093
type: Information Content Entity
most specific type: Document
crisid: 6171
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has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 695756
doi: 10.1016/j.nano.2019.102093
estado: published
pmid: 31521833
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origen: scopus
related by: authorship_39947
e iscopus: 2-s2.0-85073980175
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volume: 22
chemicalscas: amikacin, 37517-28-5, 39831-55-5; ceftazidime, 72558-82-8; ceftizoxime, 68401-81-0, 68401-82-1; ciprofloxacin, 85721-33-1; clindamycin, 18323-44-9; ertapenem, 153773-82-1, 153832-38-3, 153832-46-3; erythromycin, 114-07-8, 70536-18-4; oxacillin, 1173-88-2, 66-79-5, 7240-38-2; tobramycin, 32986-56-4; broxuridine, 59-14-3; chitosan, 9012-76-4; gold, 7440-57-5; Anti-Infective Agents; Antifungal Agents; Bromodeoxyuridine; Chitosan; Gold; Hydrogels
type: Article
related by: authorship_39949
related by: authorship_39946
related by: authorship_39950
date time value: article date 6171
has publication venue: Nanomedicine: Nanotechnology, Biology, and Medicine

Nanomedicine: Nanotechnology, Biology, and Medicine
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publication venue for: Hydrogel-embedded gold nanorods activated by plasmonic photothermy with potent antimicrobial activity

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date: 2026-08-26T23:55:57
publisher: vivo
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