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Brazilian Journal of Pharmaceutical Sciences
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publication venue for: Antinociceptive local activity of 4-allyl-1-hydroxy-2-methoxybenzene (Eugenol) by the formalin test: An anti-inflammatory effect
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type: Periodical

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RDF description of Antinociceptive local activity of 4-allyl-1-hydroxy-2-methoxybenzene (Eugenol) by the formalin test: An anti-inflammatory effect - http://orbis.uaslp.mx/vivo/individual/scopus6118
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date: 2026-08-25T22:03:51
publisher: vivo
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Article
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C18-FAI-05-50.50, C18-FAI-05-72.72, UASLP-CA-245
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type: BFO_0000020
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funding vehicle for: Antinociceptive local activity of 4-allyl-1-hydroxy-2-methoxybenzene (Eugenol) by the formalin test: An anti-inflammatory effect

Antinociceptive local activity of 4-allyl-1-hydroxy-2-methoxybenzene (Eugenol) by the formalin test: An anti-inflammatory effect
doi: 10.1590/s2175-97902019000118022
accesstype: All Open Access, Gold
related by: authorship_39273
crisid: 6119
related by: authorship_39274
type: Information Content Entity
type: Document
chemicalscas: diclofenac, 15307-79-6, 15307-86-5; eugenol, 97-53-0; naproxen, 22204-53-1, 26159-34-2; tramadol, 27203-92-5, 36282-47-0
type: Thing
has funding vehicle: C18-FAI-05-50.50, C18-FAI-05-72.72, UASLP-CA-245
date time value: article date 6119
artnum: e18022
estado: published
origen: scopus
most specific type: Document
most specific type: Article
type: Entity
type: Article
freetext keyword: Antinociception; Diclofenac effect; Eugenol/analgesic/anti-inflammatory effect; Formalin test; Pain diclofenac; eugenol; naproxen; tramadol; animal experiment; animal model; antiinflammatory activity; antinociception; Article; formalin test; male; nonhuman; pain; rat
related by: authorship_39279
type: Generically Dependent Continuant
volume: 55
related by: authorship_39276
e iscopus: 2-s2.0-85073481254
type: Continuant
related by: authorship_39275
manufactures: Novartis; Sigma Aldrich
has publication venue: Brazilian Journal of Pharmaceutical Sciences
related by: authorship_39278
related by: authorship_39277
abstract: Eugenol has been employed for decades as a condiment, an antimycotic, an antibacterial, an antiviral, and an antioxidant, and it is one of the natural analgesics most frequently utilized for pain and inflammation. Our objective was to determine the analgesic/anti-inflammatory effect of eugenol compared with diclofenac, naproxen, and tramadol using the formalin test. The formalin method was used in 6- to 10-week-old Wistar rats (weighing 250 g each) divided into six groups: Saline (0.9%25); formalin (5%25); diclofenac (250 μg/kg); naproxen (400 μg/kg); tramadol (500 μg/kg), and eugenol (1,400 μg/kg), in the intraplantar part of the hind-end trunk of the rats, with n = 5 per group. Eugenol diminished 44.4%25 of nociceptive behavior in phase 1 and 48%25 in phase 2 (p ≤0.05 vs formalin). Eugenol was shown to be 1.14 times more effective than diclofenac, but 1.62 and 1.75 times less effective than naproxen and tramadol, respectively, in phase 1 and 1.45 times less effective than diclofenac and naproxen and 1.66 less effective than tramadol in phase 2 (p ≤0.05). These data suggest that eugenol possesses moderate activity in the acute pain phase and greater activity in inflammatory-type pain, and both effects are comparable to those produced by diclofenac and are less than the effects produced by naproxen and tramadol in the formalin test. © 2019, Faculdade de Ciencias Farmaceuticas (Biblioteca). All rights reserved.