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Consejo Nacional de Ciencia y Tecnología, CONACYT: 183078, UASLP-CA-254, FAI 2017, 243298
Generically Dependent Continuant
RDF description of Differential Recovery Speed of Activity and Metabolic Rhythms in Rats After an Experimental Protocol of Shift-Work - http://orbis.uaslp.mx/vivo/individual/scopus5823
Article
The circadian system drives the temporal organization of body physiology in relation to the changing daily environment. Shift-work (SW) disrupts this temporal order and is associated with the loss of homeostasis and metabolic syndrome. In a rodent model of SW based on forced activity in the rest phase for 4 weeks, we describe the occurrence of circadian desynchrony, as well as metabolic and liver dysfunction. To provide better evidence for the impact of altered timing of activity, this study explored how long it takes to recover metabolic rhythms and behavior. Rats were submitted to experimental SW for 4 weeks and then were left to recover for one week. Daily locomotor activity, food intake patterns, serum glucose and triglycerides, and the expression levels of hepatic Pparα, Srebp-1c, Pepck, Bmal1 and Per2 were assessed during the recovery period and were compared with expected data according to a control condition. SW triggered the circadian desynchronization of all of the analyzed parameters. A difference in the time required for realignment was observed among parameters. Locomotor activity achieved the expected phase on day 2, whereas the nocturnal feeding pattern was restored on the sixth recovery day. Daily rhythms of plasma glucose and triglycerides and of Pparα, Pepck and Bmal1 expression in the liver resynchronized on the seventh day, whereas Srebp-1c and Per2 persisted arrhythmic for the entire recovery week. SW does not equally affect behavior and metabolic rhythms, leading to internal desynchrony during the recovery phase. © 2019 The Author(s).
circadian desynchrony; circadian rhythms; clock genes; liver; metabolic genes; metabolic syndrome; shift-work circadian rhythm signaling protein; triacylglycerol; animal; blood; body weight; circadian rhythm; feeding behavior; genetics; glucose blood level; liver; locomotion; male; metabolism; photoperiodicity; physiology; rat; shift schedule; time factor; Wistar rat; Animals; Blood Glucose; Body Weight; Circadian Rhythm; Feeding Behavior; Liver; Locomotion; Male; Period Circadian Proteins; Photoperiod; Rats; Rats, Wistar; Shift Work Schedule; Time Factors; Triglycerides
Differential Recovery Speed of Activity and Metabolic Rhythms in Rats After an Experimental Protocol of Shift-Work
Blood Glucose; Period Circadian Proteins; Triglycerides
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