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RDF description of Development and validation of a sensitive LC-MS/MS method for determination of betamethasone in human plasma. Application to a pharmacokinetic study of healthy Mexican subjects - http://orbis.uaslp.mx/vivo/individual/scopus5789
Article
Background: Synthetic glucocorticoids like Betamethasone (BE) are used in the treatment of inflammatory diseases due to its effective and potent effect. BE is available in three different esters: Dipropionate (BD), sodium phosphate (BP), and acetate (BA). BD/BP combined in suspension has anti-inflammatory, anti-allergic, and anti-rheumatic effects. The aim of this study was to describe the bioavailability of a single-dose of the injectable formulation of BP/BD in healthy Mexican subjects. Methods: This was a randomized, open-label, longitudinal, not therapeutic, single-dose trial of an intramuscular administration of BD/BP (5 mg/2 mg), in healthy Mexican subjects under fasting condition. Twenty-six healthy Mexicans volunteers of both genders who were between the ages of 18 and 45 were enrolled in the study. Results: From non-compartmental estimation of data, it was observed that the BE highest mean concentration was 15.70 ± 3.93 ng/mL reaching it in 2.83 ± 1.35 h. The values of elimination half-life were 10.89 ± 2.02 h. No clinically significant adverse effects were presented during the study. Conclusion: The reported PK parameters for BE suggest that the BD/BP suspension has a similar release velocity in Mexican healthy subjects compared with previous studies. © 2019 Bentham Science Publishers.
Development and validation of a sensitive LC-MS/MS method for determination of betamethasone in human plasma. Application to a pharmacokinetic study of healthy Mexican subjects
diprospan, Schering Plough, United States
Betamethasone; Dipropionate; Glucocorticoid; Human plasma; LC-MS/MS; Pharmacokinetics; Sodium phosphate betamethasone dipropionate; betamethasone sodium phosphate; carbamazepine; adult; area under the curve; Article; blood sampling; controlled study; drug bioavailability; drug determination; drug formulation; elimination half-life; fasting; female; high performance liquid chromatography; human; limit of quantitation; liquid chromatography-mass spectrometry; liquid liquid extraction; longitudinal study; male; maximum concentration; Mexican; open study; priority journal; randomized controlled trial; single drug dose; tandem mass spectrometry; time to maximum plasma concentration; ultra performance liquid chromatography; validation study; young adult
betamethasone dipropionate, 5593-20-4; betamethasone sodium phosphate, 151-73-5, 360-63-4; carbamazepine, 298-46-4, 8047-84-5
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