Document
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Generically Dependent Continuant
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individual
rights: termsOfUse
date: 2026-08-26T03:53:48
publisher: vivo
type: Document
label: RDF description of Development and validation of a sensitive LC-MS/MS method for determination of betamethasone in human plasma. Application to a pharmacokinetic study of healthy Mexican subjects - http://orbis.uaslp.mx/vivo/individual/scopus5789

Article
type: Class

Development and validation of a sensitive LC-MS/MS method for determination of betamethasone in human plasma. Application to a pharmacokinetic study of healthy Mexican subjects
volume: 15
type: Continuant
abstract: Background: Synthetic glucocorticoids like Betamethasone (BE) are used in the treatment of inflammatory diseases due to its effective and potent effect. BE is available in three different esters: Dipropionate (BD), sodium phosphate (BP), and acetate (BA). BD/BP combined in suspension has anti-inflammatory, anti-allergic, and anti-rheumatic effects. The aim of this study was to describe the bioavailability of a single-dose of the injectable formulation of BP/BD in healthy Mexican subjects. Methods: This was a randomized, open-label, longitudinal, not therapeutic, single-dose trial of an intramuscular administration of BD/BP (5 mg/2 mg), in healthy Mexican subjects under fasting condition. Twenty-six healthy Mexicans volunteers of both genders who were between the ages of 18 and 45 were enrolled in the study. Results: From non-compartmental estimation of data, it was observed that the BE highest mean concentration was 15.70 ± 3.93 ng/mL reaching it in 2.83 ± 1.35 h. The values of elimination half-life were 10.89 ± 2.02 h. No clinically significant adverse effects were presented during the study. Conclusion: The reported PK parameters for BE suggest that the BD/BP suspension has a similar release velocity in Mexican healthy subjects compared with previous studies. © 2019 Bentham Science Publishers.
date time value: article date 5790
crisid: 5790
most specific type: Article
estado: published
type: Information Content Entity
related by: authorship_36749
related by: authorship_36750
tradenames: diprospan, Schering Plough, United States
related by: authorship_36752
type: Document
freetext keyword: Betamethasone; Dipropionate; Glucocorticoid; Human plasma; LC-MS/MS; Pharmacokinetics; Sodium phosphate betamethasone dipropionate; betamethasone sodium phosphate; carbamazepine; adult; area under the curve; Article; blood sampling; controlled study; drug bioavailability; drug determination; drug formulation; elimination half-life; fasting; female; high performance liquid chromatography; human; limit of quantitation; liquid chromatography-mass spectrometry; liquid liquid extraction; longitudinal study; male; maximum concentration; Mexican; open study; priority journal; randomized controlled trial; single drug dose; tandem mass spectrometry; time to maximum plasma concentration; ultra performance liquid chromatography; validation study; young adult
has publication venue: Current Pharmaceutical Analysis
type: Thing
manufactures: Schering Plough, United States
related by: authorship_36751
type: Article
doi: 10.2174/1573412913666170912111945
origen: scopus
most specific type: Document
related by: authorship_36753
type: Entity
page end: 8
e iscopus: 2-s2.0-85059256693
chemicalscas: betamethasone dipropionate, 5593-20-4; betamethasone sodium phosphate, 151-73-5, 360-63-4; carbamazepine, 298-46-4, 8047-84-5
related by: authorship_36748
type: Generically Dependent Continuant
issue: 1
page start: 2

Information Content Entity
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Current Pharmaceutical Analysis
type: Document
type: Thing
type: Entity
type: Information Content Entity
type: Journal
type: Continuant
type: Generically Dependent Continuant
publication venue for: Development and validation of a sensitive LC-MS/MS method for determination of betamethasone in human plasma. Application to a pharmacokinetic study of healthy Mexican subjects
type: Collection
type: Periodical