Document
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European Regional Development Fund, FEDER
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funding vehicle for: Patients with Autoimmune Thyroiditis Show Diminished Levels and Defective Suppressive Function of Tr1 Regulatory Lymphocytes

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Instituto de Salud Carlos III, ISCIII
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funding vehicle for: Patients with Autoimmune Thyroiditis Show Diminished Levels and Defective Suppressive Function of Tr1 Regulatory Lymphocytes

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RDF description of Patients with Autoimmune Thyroiditis Show Diminished Levels and Defective Suppressive Function of Tr1 Regulatory Lymphocytes - http://orbis.uaslp.mx/vivo/individual/scopus5586
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date: 2026-08-24T21:50:56
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Article
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Consejo Nacional de Ciencia y Tecnología, CONACYT
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funding vehicle for: Patients with Autoimmune Thyroiditis Show Diminished Levels and Defective Suppressive Function of Tr1 Regulatory Lymphocytes

Journal of Clinical Endocrinology and Metabolism
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publication venue for: Patients with Autoimmune Thyroiditis Show Diminished Levels and Defective Suppressive Function of Tr1 Regulatory Lymphocytes

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Patients with Autoimmune Thyroiditis Show Diminished Levels and Defective Suppressive Function of Tr1 Regulatory Lymphocytes
issue: 9
has publication venue: Journal of Clinical Endocrinology and Metabolism
estado: published
crisid: 5587
related by: authorship_34704
date time value: article date 5587
has funding vehicle: European Regional Development Fund, FEDER
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT
type: Continuant
related by: authorship_34706
freetext keyword: alpha1 integrin; CD4 antigen; gamma interferon; interleukin 10; interleukin 12p70; interleukin 13; interleukin 17; interleukin 1beta; interleukin 2; interleukin 22; interleukin 4; interleukin 5; interleukin 6; tumor necrosis factor; adult; antibody titer; Article; blood; case control study; cell activation; clinical article; controlled study; cytokine release; disease duration; disease severity; endocrine ophthalmopathy; female; flow cytometry; Graves disease; Hashimoto disease; human; human cell; human tissue; immunofluorescence; lymphocyte function; male; mononuclear cell; observational study; priority journal; regulatory T lymphocyte; T lymphocyte subpopulation; thyroid gland tissue; autoimmune thyroiditis; blood; fluorescent antibody technique; Graves disease; Hashimoto disease; immunology; lymphocyte activation; middle aged; regulatory T lymphocyte; thyroid gland; Adult; Case-Control Studies; Female; Flow Cytometry; Fluorescent Antibody Technique; Graves Disease; Hashimoto Disease; Humans; Lymphocyte Activation; Male; Middle Aged; T-Lymphocytes, Regulatory; Thyroid Gland; Thyroiditis, Autoimmune
type: Entity
has funding vehicle: Instituto de Salud Carlos III, ISCIII
accesstype: All Open Access, Bronze
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related by: authorship_34702
most specific type: Article
page end: 3367
related by: authorship_34705
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origen: scopus
abstract: Context: T regulatory type 1 (Tr1) cells are a subpopulation of T lymphocytes (CD4 CD49 LAG-3 IL- 10 ) that exert a considerable immunosuppressive effect. However, their possible role in autoimmune thyroid disease (AITD) has not been explored so far. Purpose: To analyze the levels and function of Tr1 cells in peripheral blood and thyroid tissue of patients with AITD. Design: Cases and controls, observational study. Setting: Department of Endocrinology, Hospital Universitario de la Princesa, Madrid, Spain. Patients: Thirty-eight patients with AITD (23 with Graves disease and 15 with Hashimoto thyroiditis) and 26 controls. Intervention: Multiparametric flow cytometry and immunofluorescence techniques were used to analyze the levels in peripheral blood (n = 38) and thyroid mononuclear cells (n = 5). An in vitro assay of suppression of cellular activation and cytokine release was performed to study the function of Tr1 cells. Main Outcome Measure: Levels and function of Tr1 cells in patients with AITD and controls. Results: Levels of Tr1 cells were significantly diminished in peripheral blood from patients with AITD. Functional studies showed that Tr1 cells from patients with AITD exhibit a diminished suppressive function compared with healthy controls. Tr1 levels were associated with disease severity, including longer duration of the disease and ophthalmopathy activity, and with autoantibody titers. Conclusions: The low levels of Tr1 cells and their diminished function may have a relevant role in the defective immune-regulatory function characteristic of patients with AITD. © 2018 Endocrine Society.
pmid: 29982465
related by: authorship_34707
type: Article
chemicalscas: gamma interferon, 82115-62-6; interleukin 13, 148157-34-0; interleukin 2, 85898-30-2; interleukin 22, 457106-70-6, 478219-35-1, 554460-75-2
doi: 10.1210/jc.2018-00498
abstract: Context: T regulatory type 1 (Tr1) cells are a subpopulation of T lymphocytes (CD4%2bCD49%2bLAG-3%2bIL- 10%2b) that exert a considerable immunosuppressive effect. However, their possible role in autoimmune thyroid disease (AITD) has not been explored so far. Purpose: To analyze the levels and function of Tr1 cells in peripheral blood and thyroid tissue of patients with AITD. Design: Cases and controls, observational study. Setting: Department of Endocrinology, Hospital Universitario de la Princesa, Madrid, Spain. Patients: Thirty-eight patients with AITD (23 with Graves disease and 15 with Hashimoto thyroiditis) and 26 controls. Intervention: Multiparametric flow cytometry and immunofluorescence techniques were used to analyze the levels in peripheral blood (n = 38) and thyroid mononuclear cells (n = 5). An in vitro assay of suppression of cellular activation and cytokine release was performed to study the function of Tr1 cells. Main Outcome Measure: Levels and function of Tr1 cells in patients with AITD and controls. Results: Levels of Tr1 cells were significantly diminished in peripheral blood from patients with AITD. Functional studies showed that Tr1 cells from patients with AITD exhibit a diminished suppressive function compared with healthy controls. Tr1 levels were associated with disease severity, including longer duration of the disease and ophthalmopathy activity, and with autoantibody titers. Conclusions: The low levels of Tr1 cells and their diminished function may have a relevant role in the defective immune-regulatory function characteristic of patients with AITD. © 2018 Endocrine Society.
most specific type: Document
type: Information Content Entity
volume: 103
related by: authorship_34703
related by: authorship_34708
e iscopus: 2-s2.0-85054138864