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Generically Dependent Continuant
RDF description of Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children - http://orbis.uaslp.mx/vivo/individual/scopus5448
Article
butyrylcholinesterase; obesity; overweight; paraoxonase; PON1 polymorphism aryldialkylphosphatase 1; cholinesterase; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; aryldialkylphosphatase; cholinesterase; PON1 protein, human; triacylglycerol; allele; Article; body weight; child; child nutrition; childhood obesity; cholesterol blood level; controlled study; cross-sectional study; enzyme activity; female; gene frequency; genetic association; genetic polymorphism; human; human experiment; male; Mexican; normal human; nutritional status; polymerase chain reaction; priority journal; restriction fragment length polymorphism; rural population; school child; sex difference; triacylglycerol blood level; amino acid substitution; blood; case control study; genetic predisposition; genetics; genotype; metabolism; Mexico; nutritional status; obesity; physiology; Amino Acid Substitution; Aryldialkylphosphatase; Butyrylcholinesterase; Case-Control Studies; Child; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Mexico; Nutritional Status; Overweight; Pediatric Obesity; Polymorphism, Restriction Fragment Length; Triglycerides
Background: The enzymes butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are the primary bioscavenging enzymes in serum and exhibit antioxidant and anti-inflammatory activities. PON1 has been associated with diseases caused by high oxidative stress, whereas BuChE appears to be involved in the pathophysiology of the metabolic syndrome and related disorders. It has been suggested that children from rural communities in Mexico may have a predisposition to develop obesity or type 2 diabetes during adolescence or adulthood. The objective of this study was to determine whether associations exist between the paraoxonase (PONase)/arylesterase (AREase) activity of PON1, its PON1-Q192R and PON1-L55M polymorphisms, and BuChE activity with the nutritional status and lipid profiles in a group of children from rural communities in Mexico. Methods: A group of 97 boys and girls from a rural community in Mexico were assessed for body mass index, the enzymatic activities of BuChE, PONase, and AREase were measured in serum, and their lipid profiles were determined. Genetic polymorphisms of PON1-L55M and PON1-Q192R were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The children were classified into four groups: thinness, normal weight, overweight, and obese. Of the children studied, 34.4%25 were overweight and obese. The mean age of the participants was 9.5 years (standard deviation = 1.8). The L allele of the PON1-L55M genotype was the most frequent (83.3%25), and the R allele of the PON1-Q192R genotype was the most frequent (61.8%25). Overweight and obese children had higher values of BuChE, total cholesterol, triglycerides (TG), and lower high-density lipoprotein (HDL-C) values than children with thinness or normal weight (P = 0.028, P = 0.019, P = 0.004, P = 0.069 and P = 0.021, respectively). The levels of AREase and PONase and the prevalence of PON1-L55M and PON1-Q192R genotypes were similar between groups (P = 0.484 and P = 0.380, respectively). Conclusions: This study establishes a positive association of BuChE activity with nutritional status and serum TG. © Copyright 2018, Mary Ann Liebert, Inc. 2018.
Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children
cholinesterase, 9001-08-5; aryldialkylphosphatase, 117698-12-1; Aryldialkylphosphatase; Butyrylcholinesterase; PON1 protein, human; Triglycerides
Consejo Nacional de Ciencia y Tecnología, CONACYT
Metabolic Syndrome and Related Disorders
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