Document
type: Class

Continuant
type: Class

Entity
type: Class

Generically Dependent Continuant
type: Class

RDF description of Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children - http://orbis.uaslp.mx/vivo/individual/scopus5448
rights: termsOfUse
date: 2026-08-24T21:51:10
publisher: vivo
type: Document

Article
type: Class

Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children
crisid: 5449
type: Generically Dependent Continuant
related by: authorship_33883
page start: 90
related by: authorship_33879
e iscopus: 2-s2.0-85042879892
date time value: article date 5449
volume: 16
origen: scopus
type: Article
freetext keyword: butyrylcholinesterase; obesity; overweight; paraoxonase; PON1 polymorphism aryldialkylphosphatase 1; cholinesterase; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; aryldialkylphosphatase; cholinesterase; PON1 protein, human; triacylglycerol; allele; Article; body weight; child; child nutrition; childhood obesity; cholesterol blood level; controlled study; cross-sectional study; enzyme activity; female; gene frequency; genetic association; genetic polymorphism; human; human experiment; male; Mexican; normal human; nutritional status; polymerase chain reaction; priority journal; restriction fragment length polymorphism; rural population; school child; sex difference; triacylglycerol blood level; amino acid substitution; blood; case control study; genetic predisposition; genetics; genotype; metabolism; Mexico; nutritional status; obesity; physiology; Amino Acid Substitution; Aryldialkylphosphatase; Butyrylcholinesterase; Case-Control Studies; Child; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Mexico; Nutritional Status; Overweight; Pediatric Obesity; Polymorphism, Restriction Fragment Length; Triglycerides
type: Entity
type: Document
estado: published
abstract: Background: The enzymes butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are the primary bioscavenging enzymes in serum and exhibit antioxidant and anti-inflammatory activities. PON1 has been associated with diseases caused by high oxidative stress, whereas BuChE appears to be involved in the pathophysiology of the metabolic syndrome and related disorders. It has been suggested that children from rural communities in Mexico may have a predisposition to develop obesity or type 2 diabetes during adolescence or adulthood. The objective of this study was to determine whether associations exist between the paraoxonase (PONase)/arylesterase (AREase) activity of PON1, its PON1-Q192R and PON1-L55M polymorphisms, and BuChE activity with the nutritional status and lipid profiles in a group of children from rural communities in Mexico. Methods: A group of 97 boys and girls from a rural community in Mexico were assessed for body mass index, the enzymatic activities of BuChE, PONase, and AREase were measured in serum, and their lipid profiles were determined. Genetic polymorphisms of PON1-L55M and PON1-Q192R were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The children were classified into four groups: thinness, normal weight, overweight, and obese. Of the children studied, 34.4%25 were overweight and obese. The mean age of the participants was 9.5 years (standard deviation = 1.8). The L allele of the PON1-L55M genotype was the most frequent (83.3%25), and the R allele of the PON1-Q192R genotype was the most frequent (61.8%25). Overweight and obese children had higher values of BuChE, total cholesterol, triglycerides (TG), and lower high-density lipoprotein (HDL-C) values than children with thinness or normal weight (P = 0.028, P = 0.019, P = 0.004, P = 0.069 and P = 0.021, respectively). The levels of AREase and PONase and the prevalence of PON1-L55M and PON1-Q192R genotypes were similar between groups (P = 0.484 a…
type: Continuant
related by: authorship_33882
related by: authorship_33881
doi: 10.1089/met.2017.0138
type: Information Content Entity
pmid: 29393817
most specific type: Article
has funding vehicle: Instituto Politécnico Nacional, IPN
has publication venue: Metabolic Syndrome and Related Disorders
related by: authorship_33880
most specific type: Document
type: Thing
issue: 2
chemicalscas: cholinesterase, 9001-08-5; aryldialkylphosphatase, 117698-12-1; Aryldialkylphosphatase; Butyrylcholinesterase; PON1 protein, human; Triglycerides
page end: 96
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT
has funding vehicle: Secretaría de Educación Pública, SEP

Secretaría de Educación Pública, SEP
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children

Consejo Nacional de Ciencia y Tecnología, CONACYT
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children

Metabolic Syndrome and Related Disorders
type: Information Content Entity
type: Periodical
publication venue for: Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children
type: Continuant
type: Entity
type: Thing
type: Generically Dependent Continuant
type: Document
type: Collection
type: Journal

Information Content Entity
type: Class

Instituto Politécnico Nacional, IPN
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Relationship between Paraoxonase-1 and Butyrylcholinesterase Activities and Nutritional Status in Mexican Children