Document
type: Class

Continuant
type: Class

Entity
type: Class

Generically Dependent Continuant
type: Class

RDF description of Interactions of Functionalized Multi-Wall Carbon Nanotubes with Giant Phospholipid Vesicles as Model Cellular Membrane System - http://orbis.uaslp.mx/vivo/individual/scopus5341
rights: termsOfUse
date: 2026-08-24T04:45:55
publisher: vivo
type: Document

Article
type: Class

Information Content Entity
type: Class

Scientific Reports
type: Thing
type: Periodical
type: Document
type: Entity
type: Journal
type: Continuant
type: Information Content Entity
publication venue for: Interactions of Functionalized Multi-Wall Carbon Nanotubes with Giant Phospholipid Vesicles as Model Cellular Membrane System
type: Collection
type: Generically Dependent Continuant

Interactions of Functionalized Multi-Wall Carbon Nanotubes with Giant Phospholipid Vesicles as Model Cellular Membrane System
pmid: 30573758
type: Document
type: Article
has publication venue: Scientific Reports
most specific type: Article
related by: authorship_33238
chemicalscas: Coated Materials, Biocompatible; Membranes, Artificial; Nanotubes, Carbon; Phospholipids
accesstype: All Open Access, Gold, Green
volume: 8
most specific type: Document
artnum: 17998
related by: authorship_33240
crisid: 5342
estado: published
related by: authorship_33239
related by: authorship_33237
type: Thing
date time value: article date 5342
abstract: Carbon Nanotubes (CNTs) are considered alternative materials for the design of advanced drug and gene delivery vectors. However, the mechanism responsible for the cellular membrane intake of CNTs is not well understood. In the present study, we show how multi-walled carbon nanotubes (MWCNTs) owning different surface properties, interact with giant unilamellar vesicles (GUVs), a simple model system for cellular membranes. In particular, we want to address the hydrophilic/hydrophobic interactions between MWCNTs and lipid membranes and the subsequent mechanical properties changes of the systems. In order to elucidate this interaction, we made the following chemical modifications on MWCNTs: oxidized MWCNTs (ox-MWCNTs) displaying reduced hydrophobic surface character, pristine MWCNTs (p-MWCNTs), and alkyl functionalized MWCNTs (alk-MWCNTs) exhibiting enhanced hydrophobic surface properties, were put in contact with GUVs and observed by confocal microscopy. Our observations revealed that the interaction between the CNTs and GUVs depends on the type of chemical functionalization: ox-MWCNTs remain at the membrane interacting with the polar head of the phospholipids, p-MWCNTs internalize GUVs spontaneously, and alk-MWCNTs persist inside the membrane. The mechanical properties of MWCNTs%40GUVs systems were measured using the electrodeformation method, which shows an increased bending stiffness (κ) of the GUVs as MWCNTs concentration increases. High concentrations of p-MWCNTs and alk-MWCNTs induced vesicle adhesion; p-MWCNTs produced a considerable reduction in the average size of the GUVs, while alk-MWCNTs form complex stable structures inside the membrane. The statistical analyses of the experimental results are compared with available computer simulations. The picture emerging from our results is that the interaction between GUVs and MWCNTs is due mainly to hydrophobicity. © 2018, The Author(s).
origen: scopus
doi: 10.1038/s41598-018-36531-9
type: Information Content Entity
issue: 1
type: Entity
e iscopus: 2-s2.0-85058877552
abstract: Carbon Nanotubes (CNTs) are considered alternative materials for the design of advanced drug and gene delivery vectors. However, the mechanism responsible for the cellular membrane intake of CNTs is not well understood. In the present study, we show how multi-walled carbon nanotubes (MWCNTs) owning different surface properties, interact with giant unilamellar vesicles (GUVs), a simple model system for cellular membranes. In particular, we want to address the hydrophilic/hydrophobic interactions between MWCNTs and lipid membranes and the subsequent mechanical properties changes of the systems. In order to elucidate this interaction, we made the following chemical modifications on MWCNTs: oxidized MWCNTs (ox-MWCNTs) displaying reduced hydrophobic surface character, pristine MWCNTs (p-MWCNTs), and alkyl functionalized MWCNTs (alk-MWCNTs) exhibiting enhanced hydrophobic surface properties, were put in contact with GUVs and observed by confocal microscopy. Our observations revealed that the interaction between the CNTs and GUVs depends on the type of chemical functionalization: ox-MWCNTs remain at the membrane interacting with the polar head of the phospholipids, p-MWCNTs internalize GUVs spontaneously, and alk-MWCNTs persist inside the membrane. The mechanical properties of MWCNTs@GUVs systems were measured using the electrodeformation method, which shows an increased bending stiffness (κ) of the GUVs as MWCNTs concentration increases. High concentrations of p-MWCNTs and alk-MWCNTs induced vesicle adhesion; p-MWCNTs produced a considerable reduction in the average size of the GUVs, while alk-MWCNTs form complex stable structures inside the membrane. The statistical analyses of the experimental results are compared with available computer simulations. The picture emerging from our results is that the interaction between GUVs and MWCNTs is due mainly to hydrophobicity. © 2018, The Author(s).
type: Continuant
type: Generically Dependent Continuant
freetext keyword: biocompatible coated material; carbon nanotube; phospholipid; artificial membrane; biological model; cell membrane; chemical phenomena; chemistry; materials testing; mechanics; pathology; surface property; synthesis; Cell Membrane; Coated Materials, Biocompatible; Hydrophobic and Hydrophilic Interactions; Materials Testing; Mechanical Phenomena; Membranes, Artificial; Models, Biological; Nanotubes, Carbon; Phospholipids; Surface Properties
related by: authorship_33236