Document
type: Class

Chemosphere
type: Entity
type: Periodical
type: Document
publication venue for: scopus5325
type: Continuant
type: Collection
type: Thing
type: Information Content Entity
type: Generically Dependent Continuant
type: Journal

Continuant
type: Class

Entity
type: Class

Generically Dependent Continuant
type: Class

individual
rights: termsOfUse
date: 2026-08-24T18:24:28
publisher: vivo
type: Document
label: RDF description of Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction - http://orbis.uaslp.mx/vivo/individual/scopus5325

Article
type: Class

Consejo Nacional de Ciencia y Tecnología, CONACYT: PDCPN2015-1558
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: scopus5325

scopus5325
estado: published
label: Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction
page start: 770
type: Document
abstract: It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit. Urinary 1-OHP levels detected in this study ranged from 0.07 to 9.37 μmol/mol of creatinine (0.13–18.0 μg/g of creatinine). Regarding allele frequency (PON1 Q192R polymorphism), the 192Q-allele frequency was 0.43 and for the 192R-allele it was 0.57. In relation to serum ADMA levels, the levels ranged from 0.06 to 1.46 μmol/L. Moreover, multiple linear regression analysis was performed and associations between urinary 1-OHP levels (β = 0.05, p = 0.002), PON1 Q192R polymorphism (β = 0.04, p = 0.003) and serum ADMA concentrations were found. Besides, an interaction (gene-environment interaction) of both independent variables (1-OHP and PON1 polymorphism) on serum ADMA levels was found (β = 0.04, p = 0.02) in the constructed multiple linear model. Therefore, according to the significance of this research, it is necessary to execute health programs to reduce cardiovascular risk in the assessed population. © 2017 Elsevier Ltd
related by: authorship_33161
type: Article
most specific type: Article
crisid: 5326
related by: authorship_33160
origen: scopus
type: Information Content Entity
type: Entity
date time value: article date 5326
doi: 10.1016/j.chemosphere.2017.08.055
type: Continuant
volume: 186
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: PDCPN2015-1558
page end: 779
has publication venue: Chemosphere
type: Thing
chemicalscas: 1 hydroxypyrene, 5315-79-7; cholesterol, 57-88-5; creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; n(g),n(g) dimethylarginine, 30315-93-6; arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; aryldialkylphosphatase, 117698-12-1; 1-hydroxypyrene; Arginine; Aryldialkylphosphatase; Biomarkers; Creatinine; dimethylarginine; Environmental Pollutants; N,N-dimethylarginine; Polycyclic Aromatic Hydrocarbons; PON1 protein, human; Pyrenes
freetext keyword: 1-Hydroxypyrene; Asymmetric dimethylarginine; Cardiovascular diseases; Gene-environment interaction; Polycyclic aromatic hydrocarbons; PON1 polymorphism Aromatization; Cardiology; Diseases; Genes; Health risks; High performance liquid chromatography; Linear regression; Mineral oils; Polymorphism; Risk assessment; 1-Hydroxypyrene; Asymmetric dimethylarginine; Cardio-vascular disease; Gene-environment interaction; Genetic susceptibility; Multiple linear models; Multiple linear regression analysis; Polycyclic aromatic hydrocarbons (PAHS); Polycyclic aromatic hydrocarbons; 1 hydroxypyrene; aryldialkylphosphatase 1; biological marker; cholesterol; creatinine; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; n(g),n(g) dimethylarginine; triacylglycerol; 1-hydroxypyrene; arginine; aryldialkylphosphatase; biological marker; creatinine; dimethylarginine; N,N-dimethylarginine; polycyclic aromatic hydrocarbon; PON1 protein, human; pyrene derivative; biomarker; cardiovascular disease; concentration (composition); genotype-environment interaction; health risk; immunoassay; organic compound; PAH; polymorphism; public health; pyrene; serum; womens health; adult; aged; Article; blood level; blood sampling; cardiovascular risk; cholesterol blood level; creatinine urine level; cross-sectional study; environmental exposure; enzyme linked immunosorbent assay; female; gene frequency; genetic polymorphism; genetic susceptibility; genotype; genotype environment interaction; genotyping technique; glucose blood level; high performance liquid chromatography; homozygosity; human; major clinical study; Mexican; triacylglycerol blood level; urine sampling; allele; analogs and derivatives; analysis; blood; cardiovascular disease; environmental exposure; genetic polymorphism; genetic predisposition; genetics; metabolism; Mexico; pollutant; risk factor; urine; Federal District [Mexico]; Mexico City; Mexico [North America]; Adult; Alleles; Arginine; Aryldialkylphos…
e iscopus: 2-s2.0-85027401524
related by: authorship_33159
related by: authorship_33163
related by: authorship_33162
pmid: 28821001
most specific type: Document
type: Generically Dependent Continuant

Information Content Entity
type: Class