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RDF description of Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction - http://orbis.uaslp.mx/vivo/individual/scopus5325
Article
Consejo Nacional de Ciencia y Tecnología, CONACYT: PDCPN2015-1558
Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction
It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit. Urinary 1-OHP levels detected in this study ranged from 0.07 to 9.37 μmol/mol of creatinine (0.13–18.0 μg/g of creatinine). Regarding allele frequency (PON1 Q192R polymorphism), the 192Q-allele frequency was 0.43 and for the 192R-allele it was 0.57. In relation to serum ADMA levels, the levels ranged from 0.06 to 1.46 μmol/L. Moreover, multiple linear regression analysis was performed and associations between urinary 1-OHP levels (β = 0.05, p = 0.002), PON1 Q192R polymorphism (β = 0.04, p = 0.003) and serum ADMA concentrations were found. Besides, an interaction (gene-environment interaction) of both independent variables (1-OHP and PON1 polymorphism) on serum ADMA levels was found (β = 0.04, p = 0.02) in the constructed multiple linear model. Therefore, according to the significance of this research, it is necessary to execute health programs to reduce cardiovascular risk in the assessed population. © 2017 Elsevier Ltd
1 hydroxypyrene, 5315-79-7; cholesterol, 57-88-5; creatinine, 19230-81-0, 60-27-5; glucose, 50-99-7, 84778-64-3; n(g),n(g) dimethylarginine, 30315-93-6; arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; aryldialkylphosphatase, 117698-12-1; 1-hydroxypyrene; Arginine; Aryldialkylphosphatase; Biomarkers; Creatinine; dimethylarginine; Environmental Pollutants; N,N-dimethylarginine; Polycyclic Aromatic Hydrocarbons; PON1 protein, human; Pyrenes
1-Hydroxypyrene; Asymmetric dimethylarginine; Cardiovascular diseases; Gene-environment interaction; Polycyclic aromatic hydrocarbons; PON1 polymorphism Aromatization; Cardiology; Diseases; Genes; Health risks; High performance liquid chromatography; Linear regression; Mineral oils; Polymorphism; Risk assessment; 1-Hydroxypyrene; Asymmetric dimethylarginine; Cardio-vascular disease; Gene-environment interaction; Genetic susceptibility; Multiple linear models; Multiple linear regression analysis; Polycyclic aromatic hydrocarbons (PAHS); Polycyclic aromatic hydrocarbons; 1 hydroxypyrene; aryldialkylphosphatase 1; biological marker; cholesterol; creatinine; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; n(g),n(g) dimethylarginine; triacylglycerol; 1-hydroxypyrene; arginine; aryldialkylphosphatase; biological marker; creatinine; dimethylarginine; N,N-dimethylarginine; polycyclic aromatic hydrocarbon; PON1 protein, human; pyrene derivative; biomarker; cardiovascular disease; concentration (composition); genotype-environment interaction; health risk; immunoassay; organic compound; PAH; polymorphism; public health; pyrene; serum; womens health; adult; aged; Article; blood level; blood sampling; cardiovascular risk; cholesterol blood level; creatinine urine level; cross-sectional study; environmental exposure; enzyme linked immunosorbent assay; female; gene frequency; genetic polymorphism; genetic susceptibility; genotype; genotype environment interaction; genotyping technique; glucose blood level; high performance liquid chromatography; homozygosity; human; major clinical study; Mexican; triacylglycerol blood level; urine sampling; allele; analogs and derivatives; analysis; blood; cardiovascular disease; environmental exposure; genetic polymorphism; genetic predisposition; genetics; metabolism; Mexico; pollutant; risk factor; urine; Federal District [Mexico]; Mexico City; Mexico [North America]; Adult; Alleles; Arginine; Aryldialkylphosphatase; Biomarkers; Cardiovascular Diseases; Creatinine; Environmental Exposure; Environmental Pollutants; Female; Gene Frequency; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Mexico; Polycyclic Aromatic Hydrocarbons; Polymorphism, Genetic; Pyrenes; Risk Factors
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