Document
type: Class

Consejo Nacional de Ciencia y Tecnología, CONACYT: 181577
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: In utero exposure to fluoride and cognitive development delay in infants

Universidad de Guanajuato, UG: FO-DAI-05, 239404
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: In utero exposure to fluoride and cognitive development delay in infants

Continuant
type: Class

Entity
type: Class

Generically Dependent Continuant
type: Class

RDF description of In utero exposure to fluoride and cognitive development delay in infants - http://orbis.uaslp.mx/vivo/individual/scopus5226
rights: termsOfUse
date: 2026-08-28T02:20:18
publisher: vivo
type: Document

Article
type: Class

NeuroToxicology
publication venue for: In utero exposure to fluoride and cognitive development delay in infants
type: Continuant
type: Journal
type: Periodical
type: Generically Dependent Continuant
type: Document
type: Information Content Entity
type: Entity
type: Collection
type: Thing

In utero exposure to fluoride and cognitive development delay in infants
origen: scopus
type: Continuant
doi: 10.1016/j.neuro.2016.12.011
type: Generically Dependent Continuant
related by: authorship_31773
has publication venue: NeuroToxicology
has funding vehicle: Universidad de Guanajuato, UG: FO-DAI-05, 239404
most specific type: Document
e iscopus: 2-s2.0-85011079600
related by: authorship_31779
related by: authorship_31778
type: Document
abstract: The objective of this study was to evaluate the association between in utero exposure to fluoride (F) and Mental and Psychomotor Development (MDI and PDI) evaluated through the Bayley Scale of Infant Development II (BSDI-II) in infants. The sample included 65 mother-infant pairs. Environmental exposure to F was quantified in tap and bottled water samples and F in maternal urine was the biological exposure indicator; samples were collected during the 1st, 2nd and 3rd trimester of pregnancy. The mean values of F in tap water for the 1st, 2nd and 3rd trimester were 2.6 ± 1.1 mg/l, 3.1 ± 1.1 mg/l and 3.7 ± 1.0 mg/l respectively; above to 80%25 of the samples exceeded the reference value of 1.5 mg/l (NOM-127-SSA1-1994). Regarding F in maternal urine, mean values were 1.9 ± 1.0 mg/l, 2.0 ± 1.1 mg/l and 2.7 ± 1.1 mg/l for the 1st, 2nd and 3rd trimester respectively. The infants with MDI and PDI scores less than 85 points were 38.5%25 and 20.9%25 respectively. After adjusting for potential confounding factors (gestational age, age of child, marginalization index and type of water for consumption), the MDI showed an inverse association with F levels in maternal urine for the first (β = −19.05, p = 0.04) and second trimester (β = −19.34, p = 0.01). Our data suggests that cognitive alterations in children born from exposed mothers to F could start in early prenatal stages of life. © 2017
pmid: 28077305
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 181577
estado: published
related by: authorship_31777
page end: 70
type: Information Content Entity
freetext keyword: Cognitive development delay; Fluoride exposure in utero; Infant fluoride; anticaries agent; fluoride; adolescent; adult; age; Article; Bayley Scales of Infant Development; blood brain barrier; cognitive development; controlled study; developmental disorder; environmental exposure; female; first trimester pregnancy; fluid intake; fluorosis; gestational age; human; hydrofluorosis; mental development; placental transfer; prenatal development; psychomotor development; second trimester pregnancy; third trimester pregnancy; urinalysis; water sampling; chemically induced; cognitive defect; developmental disorder; infant; male; maternal exposure; Mexico; pathophysiology; pregnancy; prenatal exposure; young adult; Adolescent; Adult; Cariostatic Agents; Cognition Disorders; Developmental Disabilities; Female; Fluorides; Humans; Infant; Male; Maternal Exposure; Mexico; Pregnancy; Prenatal Exposure Delayed Effects; Young Adult
related by: authorship_31776
type: Article
crisid: 5227
date time value: article date 5227
type: Entity
volume: 59
type: Thing
chemicalscas: fluoride, 16984-48-8; Cariostatic Agents; Fluorides
most specific type: Article
page start: 65
related by: authorship_31775
related by: authorship_31774

Information Content Entity
type: Class