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RDF description of Tau protein in oral mucosa and cognitive state: A cross-sectional study - http://orbis.uaslp.mx/vivo/individual/scopus5205
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date: 2026-08-24T21:51:13
publisher: vivo
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Article
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Tau protein in oral mucosa and cognitive state: A cross-sectional study
related by: authorship_31657
has publication venue: Frontiers in Neurology
issue: OCT
related by: authorship_31662
most specific type: Article
related by: authorship_31660
related by: authorship_31668
related by: authorship_31667
freetext keyword: Alzheimer disease; Dementia; Neurodegenerative diseases; Oral mucosa cells; Tau protein tau protein; aged; Article; cognitive defect; confocal microscopy; controlled study; cross-sectional study; cytoplasm; disease severity; female; flow cytometry; genetic transcription; human; immunocytochemistry; immunofluorescence; major clinical study; male; mild cognitive impairment; Mini Mental State Examination; mouth mucosa; positron emission tomography-computed tomography; protein expression; protein localization; quantitative analysis; real time polymerase chain reaction
abstract: Neurodegenerative diseases are characterized by the presence of abnormal aggregates of proteins in brain tissue. Among them, the presence of aggregates of phosphorylated Tau protein (p-Tau) is the hallmark of Alzheimer%27s disease (AD) and other major neurodegenerative disorders such as corticobasal degeneration and frontotemporal dementia among others. Although Tau protein has previously been assumed to be exclusive to the central nervous system, it is also found in peripheral tissues. The purpose of this study was to determine whether there is a differential Tau expression in oral mucosa cells according to cognitive impairment. Eighty-one subjects were enrolled in the study and classified per Mini-Mental State Examination test score into control, mild cognitive impairment (MCI), and severe cognitive impairment (SCI) groups. Immunocytochemistry and immunofluorescence revealed the presence of Tau and four p-Tau forms in the cytoplasm and nucleus of oral mucosa cells. More positivity was present in subjects with cognitive impairment than in control subjects, both in the nucleus and cytoplasm, in a speckle pattern. The mRNA expression of Tau by quantitative real-time polymerase chain reaction was higher in SCI as compared with the control group (P < 0.01). A significantly higher percentage of immunopositive cells in the SCI group was found via flow cytometry in comparison to controls and the MCI group (P < 0.01). These findings demonstrate the higher presence of p-Tau and Tau transcript in the oral mucosa of cognitively impaired subjects when compared with healthy subjects. The feasibility of p-Tau quantification by flow cytometry supports the prospective analysis of oral mucosa as a support tool for screening of proteinopathies in cognitively impaired patients. © 2017 Arredondo, Aranda-Romo, Rodríguez-Leyva, Chi-Ahumada, Saikaly, Portales-Pérez, González-Amaro, Salgado-Bustamante, Enriquez-Macias, Eng, Norman and Jimenez-Capdeville.
related by: authorship_31658
type: Document
type: Article
type: Entity
related by: authorship_31659
crisid: 5206
e iscopus: 2-s2.0-85031043712
accesstype: All Open Access, Gold, Green
related by: authorship_31665
type: Continuant
origen: scopus
related by: authorship_31666
estado: published
volume: 8
abstract: Neurodegenerative diseases are characterized by the presence of abnormal aggregates of proteins in brain tissue. Among them, the presence of aggregates of phosphorylated Tau protein (p-Tau) is the hallmark of Alzheimer's disease (AD) and other major neurodegenerative disorders such as corticobasal degeneration and frontotemporal dementia among others. Although Tau protein has previously been assumed to be exclusive to the central nervous system, it is also found in peripheral tissues. The purpose of this study was to determine whether there is a differential Tau expression in oral mucosa cells according to cognitive impairment. Eighty-one subjects were enrolled in the study and classified per Mini-Mental State Examination test score into control, mild cognitive impairment (MCI), and severe cognitive impairment (SCI) groups. Immunocytochemistry and immunofluorescence revealed the presence of Tau and four p-Tau forms in the cytoplasm and nucleus of oral mucosa cells. More positivity was present in subjects with cognitive impairment than in control subjects, both in the nucleus and cytoplasm, in a speckle pattern. The mRNA expression of Tau by quantitative real-time polymerase chain reaction was higher in SCI as compared with the control group (P < 0.01). A significantly higher percentage of immunopositive cells in the SCI group was found via flow cytometry in comparison to controls and the MCI group (P < 0.01). These findings demonstrate the higher presence of p-Tau and Tau transcript in the oral mucosa of cognitively impaired subjects when compared with healthy subjects. The feasibility of p-Tau quantification by flow cytometry supports the prospective analysis of oral mucosa as a support tool for screening of proteinopathies in cognitively impaired patients. © 2017 Arredondo, Aranda-Romo, Rodríguez-Leyva, Chi-Ahumada, Saikaly, Portales-Pérez, González-Amaro, Salgado-Bustamante, Enriquez-Macias, Eng, Norman and Jimenez-Capdeville.
date time value: article date 5206
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most specific type: Document
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type: Generically Dependent Continuant
artnum: 554
related by: authorship_31664
related by: authorship_31663
related by: authorship_31661
doi: 10.3389/fneur.2017.00554

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Frontiers in Neurology
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publication venue for: Tau protein in oral mucosa and cognitive state: A cross-sectional study