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Comparison between Sprague-Dawley and Wistar rats as an experimental model of pharmacokinetic alterations induced by spinal cord injury
Two strains of rats, Sprague-Dawley and Wistar, were assayed in order to determine which strain is the more suitable experimental model for the study of pharmacokinetic alterations induced by spinal cord injury. Animals were submitted to spinal cord contusion at the T8-T9 level by the weight drop method. A single acetaminophen oral dose (100 mg/kg) was administered 24 h after injury and blood samples were drawn for a period of 4 h. Acetaminophen concentration in whole blood was determined by high performance liquid chromatography and pharmacokinetic parameters were estimated. For both strains, C(max) and AUC were significantly lower,whereas t(max) remained unchanged, in injured animals compared to sham-injured controls. Circulating acetaminophen concentrations were higher; therefore, pharmacokinetic alterations were more easily discerned, in Sprague-Dawley than in Wistar rats. It is concluded that the Sprague-Dawley strain is a more suitable model for the study of pharmacokinetic alterations induced by spinal cord injury.
Acetaminophen; Pharmacokinetics; Spinal cord injury; Sprague-Dawley rats; Wistar rats antipyretic analgesic agent; paracetamol; animal experiment; animal model; area under the curve; article; controlled study; drug blood level; female; high performance liquid chromatography; nonhuman; oral drug administration; rat; spinal cord injury; strain difference; thoracic spine; Acetaminophen; Administration, Oral; Animals; Area Under Curve; Biological Availability; Female; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spinal Cord Injuries
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