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Comparison between Sprague-Dawley and Wistar rats as an experimental model of pharmacokinetic alterations induced by spinal cord injury
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page end: 457
has publication venue: Archives of Medical Research
type: Continuant
pmid: 8987177
related by: authorship 2196
chemicalscas: Acetaminophen, 103-90-2
related by: authorship 2198
e iscopus: 2-s2.0-0029826111
type: Generically Dependent Continuant
most specific type: Document
issue: 4
type: Document
date time value: article date 488
abstract: Two strains of rats, Sprague-Dawley and Wistar, were assayed in order to determine which strain is the more suitable experimental model for the study of pharmacokinetic alterations induced by spinal cord injury. Animals were submitted to spinal cord contusion at the T8-T9 level by the weight drop method. A single acetaminophen oral dose (100 mg/kg) was administered 24 h after injury and blood samples were drawn for a period of 4 h. Acetaminophen concentration in whole blood was determined by high performance liquid chromatography and pharmacokinetic parameters were estimated. For both strains, C(max) and AUC were significantly lower,whereas t(max) remained unchanged, in injured animals compared to sham-injured controls. Circulating acetaminophen concentrations were higher; therefore, pharmacokinetic alterations were more easily discerned, in Sprague-Dawley than in Wistar rats. It is concluded that the Sprague-Dawley strain is a more suitable model for the study of pharmacokinetic alterations induced by spinal cord injury.
origen: scopus
related by: authorship 2201
volume: 27
related by: authorship 2203
type: Thing
type: Article
crisid: 488
related by: authorship 2199
related by: authorship 2197
manufactures: sigma, United States
type: Information Content Entity
related by: authorship 2200
page start: 453
estado: published
related by: authorship 2202
most specific type: Article
freetext keyword: Acetaminophen; Pharmacokinetics; Spinal cord injury; Sprague-Dawley rats; Wistar rats antipyretic analgesic agent; paracetamol; animal experiment; animal model; area under the curve; article; controlled study; drug blood level; female; high performance liquid chromatography; nonhuman; oral drug administration; rat; spinal cord injury; strain difference; thoracic spine; Acetaminophen; Administration, Oral; Animals; Area Under Curve; Biological Availability; Female; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spinal Cord Injuries

Archives of Medical Research
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publication venue for: Comparison between Sprague-Dawley and Wistar rats as an experimental model of pharmacokinetic alterations induced by spinal cord injury
type: Generically Dependent Continuant
type: Journal
type: Document

individual
rights: termsOfUse
date: 2026-08-25T21:07:47
publisher: vivo
type: Document
label: RDF description of Comparison between Sprague-Dawley and Wistar rats as an experimental model of pharmacokinetic alterations induced by spinal cord injury - http://orbis.uaslp.mx/vivo/individual/scopus487

Article
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