Generically Dependent Continuant
RDF description of Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1 - http://orbis.uaslp.mx/vivo/individual/scopus4839
Article
Harvard T.H. Chan School of Public Health, HSPH
National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK: R01DK072381
Document
Consejo Nacional de Ciencia y Tecnología, CONACYT: 234833
National Institute of Environmental Health Sciences, NIEHS: P30ES000002, R01ES017543
Information Content Entity
Arsenic; Children; Chromium; KIM-1; miRNAs arsenic; biological marker; cadmium; chromium; creatinine; drinking water; fluoride; kidney injury molecule 1; lead; microRNA 200c; neutrophil gelatinase associated lipocalin; tap water; well water; arsenic; biological marker; chromium; creatinine; drinking water; fluoride; ground water; HAVCR1 protein, human; kidney injury molecule 1; LCN2 protein, human; lead; microRNA; MIRN200 microRNA, human; MIRN21 microRNA, human; MIRN423 microRNA, human; neutrophil gelatinase associated lipocalin; pollutant; serum albumin; anthropogenic source; arsenic; biomarker; child health; chromium; environmental fate; environmental hazard; genome; injury; pollution exposure; toxicity; vulnerability; World Health Organization; albuminuria; Article; blood sampling; body mass; child; child health; childhood disease; chronic kidney disease; creatinine blood level; cross-sectional study; disease association; environmental exposure; female; glomerulus filtration rate; human; kidney injury; major clinical study; male; Mexico; priority journal; reverse transcription; RNA isolation; susceptible population; urinalysis; water sampling; world health organization; analysis; blood; environmental exposure; kidney disease; metabolism; pollutant; preschool child; urine; Mexico [North America]; San Luis Potosi; Villa de Reyes; Arsenic; Biomarkers; Child; Child, Preschool; Chromium; Creatinine; Drinking Water; Environmental Exposure; Environmental Pollutants; Female; Fluorides; Glomerular Filtration Rate; Groundwater; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney Diseases; Lead; Lipocalin-2; Male; Mexico; MicroRNAs; Serum Albumin
Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1
Environmental hazards from natural or anthropological sources are widespread, especially in the north-central region of Mexico. Children represent a susceptible population due to their unique routes of exposure and special vulnerabilities. In this study we evaluated the association of exposure to environmental kidney toxicants with kidney injury biomarkers in children living in San Luis Potosi (SLP), Mexico. A cross-sectional study was conducted with 83 children (5–12 years of age) residents of Villa de Reyes, SLP. Exposure to arsenic, cadmium, chromium, fluoride and lead was assessed in urine, blood and drinking water samples. Almost all tap and well water samples had levels of arsenic (81.5%25) and fluoride (100%25) above the permissible levels recommended by the World Health Organization. Mean urine arsenic (45.6 ppb) and chromium (61.7 ppb) were higher than the biological exposure index, a reference value in occupational settings. Using multivariate adjusted models, we found a dose-dependent association between kidney injury molecule-1 (KIM-1) across chromium exposure tertiles [(T1: reference, T2: 467 pg/mL; T3: 615 pg/mL) (p-trend=0.001)]. Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/μl) and miR-423 (189 copies/μL). Arsenic upper tertile was also associated with higher urinary KIM-1 (372 pg/mL). Other kidney injury/functional biomarkers such as serum creatinine, glomerular filtration rate, albuminuria, neutrophil gelatinase-associated lipocalin and miR-21 did not show any association with arsenic, chromium or any of the other toxicants evaluated. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents. © 2016 Elsevier Inc.
arsenic, 7440-38-2; cadmium, 22537-48-0, 7440-43-9; chromium, 16065-83-1, 7440-47-3, 14092-98-9; creatinine, 19230-81-0, 60-27-5; fluoride, 16984-48-8; lead, 7439-92-1, 13966-28-4; serum albumin, 9048-46-8; Arsenic; Biomarkers; Chromium; Creatinine; Drinking Water; Environmental Pollutants; Fluorides; HAVCR1 protein, human; Hepatitis A Virus Cellular Receptor 1; LCN2 protein, human; Lead; Lipocalin-2; MicroRNAs; MIRN200 microRNA, human; MIRN21 microRNA, human; MIRN423 microRNA, human; Serum Albumin