Environmental Research
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publication venue for: Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1
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ES017543
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funding vehicle for: Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1

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RDF description of Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1 - http://orbis.uaslp.mx/vivo/individual/scopus4839
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date: 2026-08-24T18:21:20
publisher: vivo
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Article
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Harvard T.H. Chan School of Public Health, HSPH
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funding vehicle for: Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1

National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK: R01DK072381
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Fundación México en Harvard, FMH
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Consejo Nacional de Ciencia y Tecnología, CONACYT: 234833
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National Institute of Environmental Health Sciences, NIEHS: P30ES000002, R01ES017543
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Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1
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related by: authorship_28912
freetext keyword: Arsenic; Children; Chromium; KIM-1; miRNAs arsenic; biological marker; cadmium; chromium; creatinine; drinking water; fluoride; kidney injury molecule 1; lead; microRNA 200c; neutrophil gelatinase associated lipocalin; tap water; well water; arsenic; biological marker; chromium; creatinine; drinking water; fluoride; ground water; HAVCR1 protein, human; kidney injury molecule 1; LCN2 protein, human; lead; microRNA; MIRN200 microRNA, human; MIRN21 microRNA, human; MIRN423 microRNA, human; neutrophil gelatinase associated lipocalin; pollutant; serum albumin; anthropogenic source; arsenic; biomarker; child health; chromium; environmental fate; environmental hazard; genome; injury; pollution exposure; toxicity; vulnerability; World Health Organization; albuminuria; Article; blood sampling; body mass; child; child health; childhood disease; chronic kidney disease; creatinine blood level; cross-sectional study; disease association; environmental exposure; female; glomerulus filtration rate; human; kidney injury; major clinical study; male; Mexico; priority journal; reverse transcription; RNA isolation; susceptible population; urinalysis; water sampling; world health organization; analysis; blood; environmental exposure; kidney disease; metabolism; pollutant; preschool child; urine; Mexico [North America]; San Luis Potosi; Villa de Reyes; Arsenic; Biomarkers; Child; Child, Preschool; Chromium; Creatinine; Drinking Water; Environmental Exposure; Environmental Pollutants; Female; Fluorides; Glomerular Filtration Rate; Groundwater; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney Diseases; Lead; Lipocalin-2; Male; Mexico; MicroRNAs; Serum Albumin
has funding vehicle: ES017543
type: Generically Dependent Continuant
has funding vehicle: National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK: R01DK072381
has publication venue: Environmental Research
volume: 150
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origen: scopus
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related by: authorship_28903
most specific type: Document
most specific type: Article
has funding vehicle: Harvard T.H. Chan School of Public Health, HSPH
related by: authorship_28911
doi: 10.1016/j.envres.2016.06.032
has funding vehicle: National Institute of Environmental Health Sciences, NIEHS: P30ES000002, R01ES017543
type: Continuant
related by: authorship_28914
abstract: Environmental hazards from natural or anthropological sources are widespread, especially in the north-central region of Mexico. Children represent a susceptible population due to their unique routes of exposure and special vulnerabilities. In this study we evaluated the association of exposure to environmental kidney toxicants with kidney injury biomarkers in children living in San Luis Potosi (SLP), Mexico. A cross-sectional study was conducted with 83 children (5–12 years of age) residents of Villa de Reyes, SLP. Exposure to arsenic, cadmium, chromium, fluoride and lead was assessed in urine, blood and drinking water samples. Almost all tap and well water samples had levels of arsenic (81.5%25) and fluoride (100%25) above the permissible levels recommended by the World Health Organization. Mean urine arsenic (45.6 ppb) and chromium (61.7 ppb) were higher than the biological exposure index, a reference value in occupational settings. Using multivariate adjusted models, we found a dose-dependent association between kidney injury molecule-1 (KIM-1) across chromium exposure tertiles [(T1: reference, T2: 467 pg/mL; T3: 615 pg/mL) (p-trend=0.001)]. Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/μl) and miR-423 (189 copies/μL). Arsenic upper tertile was also associated with higher urinary KIM-1 (372 pg/mL). Other kidney injury/functional biomarkers such as serum creatinine, glomerular filtration rate, albuminuria, neutrophil gelatinase-associated lipocalin and miR-21 did not show any association with arsenic, chromium or any of the other toxicants evaluated. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents. © 2016 Elsevier Inc.
related by: authorship_28905
date time value: article date 4840
related by: authorship_28907
pmid: 27431456
chemicalscas: arsenic, 7440-38-2; cadmium, 22537-48-0, 7440-43-9; chromium, 16065-83-1, 7440-47-3, 14092-98-9; creatinine, 19230-81-0, 60-27-5; fluoride, 16984-48-8; lead, 7439-92-1, 13966-28-4; serum albumin, 9048-46-8; Arsenic; Biomarkers; Chromium; Creatinine; Drinking Water; Environmental Pollutants; Fluorides; HAVCR1 protein, human; Hepatitis A Virus Cellular Receptor 1; LCN2 protein, human; Lead; Lipocalin-2; MicroRNAs; MIRN200 microRNA, human; MIRN21 microRNA, human; MIRN423 microRNA, human; Serum Albumin
accesstype: All Open Access, Green
related by: authorship_28913
related by: authorship_28910
type: Document
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 234833
type: Information Content Entity
crisid: 4840
related by: authorship_28904
estado: published
type: Article
page end: 662
related by: authorship_28909
has funding vehicle: Fundación México en Harvard, FMH
page start: 653
related by: authorship_28906