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Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects
Defects; Disease control; Free radical polymerization; Free radicals; Scaffolds (biology); Stem cells; Strontium; Tissue; Tissue regeneration; Bone regeneration; Critical sized defects; Cytocompatibility; Dental pulp stem cells; Pharmaceutical fields; Pluripotent stem cells; Semi-interpenetrating networks; Tri-calcium phosphates; Bone; calcium phosphate; chitosan; folic acid derivative; free radical; macrogol; strontium folate; unclassified drug; folic acid; strontium; animal experiment; animal model; animal tissue; Article; bone regeneration; bone tissue; calvaria; controlled study; dental pulp stem cell; female; freeze drying; human; human cell; in vitro study; in vivo study; nanofabrication; nonhuman; ossification; osteolysis; pluripotent stem cell; polymerization; priority journal; rat; skull defect; stem cell transplantation; tissue scaffold; animal; bone regeneration; chemistry; cytology; drug effects; stem cell; tooth pulp; Animals; Bone Regeneration; Dental Pulp; Folic Acid; Humans; Rats; Stem Cells; Strontium; Tissue Scaffolds
Strontium folate (SrFO) is a recently developed bone promoting agent with interest in medical and pharmaceutical fields due to its improved features in comparison to current strontium based therapies for osteoporosis and other bone diseases. In this work SrFO derivative was synthesized and loaded into biohybrid scaffolds obtained through lyophilisation of semi-interpenetrating networks of chitosan polyethylene glycol dimethacrylate and beta tri-calcium phosphate (βTCP) fabricated using free radical polymerization. The scaffolds were seeded with pluripotent stem cells obtained from human dental pulp and their potential to regenerate bone tissues were assessed using a critical sized defect model of calvaria in rats and compared with those obtained without SrFO. The results obtained both in vitro and in vivo demonstrated excellent cyto-compatibility with resorption of scaffolds in 4-6 weeks and a total regeneration of the defect, with a more rapid and dense bone formation in the group with SrFO. Thus, the use of stem cells sourced from human dental pulp in combination with SrFO are very promising systems for their application in compromised osseous tissue regeneration. © The Royal Society of Chemistry 2016.
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Comisión Interministerial de Ciencia y Tecnología, CICYT: MAT2010-18155
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Consejo Nacional de Ciencia y Tecnología, CONACYT: 270973, 334344
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