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PIEF-GA2013-622280
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funding vehicle for: Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects

Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects
type: Document
origen: scopus
type: Information Content Entity
doi: 10.1039/c6bm00459h
type: Thing
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pmid: 27722231
has publication venue: Biomaterials Science
date time value: article date 4678
page end: 1604
related by: authorship_27464
type: Article
related by: authorship_27466
related by: authorship_27460
has funding vehicle: Comisión Interministerial de Ciencia y Tecnología, CICYT: MAT2010-18155
crisid: 4678
most specific type: Article
related by: authorship_27463
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 270973, 334344
related by: authorship_27465
type: Continuant
related by: authorship_27462
e iscopus: 2-s2.0-84991829470
type: Generically Dependent Continuant
related by: authorship_27467
related by: authorship_27461
chemicalscas: calcium phosphate, 10103-46-5, 13767-12-9, 14358-97-5, 7758-87-4; chitosan, 9012-76-4; macrogol, 25322-68-3; folic acid, 59-30-3, 6484-89-5; strontium, 7440-24-6; Folic Acid; Strontium
issue: 11
freetext keyword: Defects; Disease control; Free radical polymerization; Free radicals; Scaffolds (biology); Stem cells; Strontium; Tissue; Tissue regeneration; Bone regeneration; Critical sized defects; Cytocompatibility; Dental pulp stem cells; Pharmaceutical fields; Pluripotent stem cells; Semi-interpenetrating networks; Tri-calcium phosphates; Bone; calcium phosphate; chitosan; folic acid derivative; free radical; macrogol; strontium folate; unclassified drug; folic acid; strontium; animal experiment; animal model; animal tissue; Article; bone regeneration; bone tissue; calvaria; controlled study; dental pulp stem cell; female; freeze drying; human; human cell; in vitro study; in vivo study; nanofabrication; nonhuman; ossification; osteolysis; pluripotent stem cell; polymerization; priority journal; rat; skull defect; stem cell transplantation; tissue scaffold; animal; bone regeneration; chemistry; cytology; drug effects; stem cell; tooth pulp; Animals; Bone Regeneration; Dental Pulp; Folic Acid; Humans; Rats; Stem Cells; Strontium; Tissue Scaffolds
most specific type: Document
abstract: Strontium folate (SrFO) is a recently developed bone promoting agent with interest in medical and pharmaceutical fields due to its improved features in comparison to current strontium based therapies for osteoporosis and other bone diseases. In this work SrFO derivative was synthesized and loaded into biohybrid scaffolds obtained through lyophilisation of semi-interpenetrating networks of chitosan polyethylene glycol dimethacrylate and beta tri-calcium phosphate (βTCP) fabricated using free radical polymerization. The scaffolds were seeded with pluripotent stem cells obtained from human dental pulp and their potential to regenerate bone tissues were assessed using a critical sized defect model of calvaria in rats and compared with those obtained without SrFO. The results obtained both in vitro and in vivo demonstrated excellent cyto-compatibility with resorption of scaffolds in 4-6 weeks and a total regeneration of the defect, with a more rapid and dense bone formation in the group with SrFO. Thus, the use of stem cells sourced from human dental pulp in combination with SrFO are very promising systems for their application in compromised osseous tissue regeneration. © The Royal Society of Chemistry 2016.
volume: 4
has funding vehicle: PIEF-GA2013-622280
estado: published
page start: 1596

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individual
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date: 2026-08-24T21:51:12
publisher: vivo
type: Document
label: RDF description of Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects - http://orbis.uaslp.mx/vivo/individual/scopus4677

Comisión Interministerial de Ciencia y Tecnología, CICYT: MAT2010-18155
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type: BFO_0000020
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funding vehicle for: Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects

Article
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Consejo Nacional de Ciencia y Tecnología, CONACYT: 270973, 334344
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type: BFO_0000020
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funding vehicle for: Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects

Information Content Entity
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Biomaterials Science
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publication venue for: Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce: In vivo bone regeneration in critical sized defects
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