Document
type: Class

Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: A randomized clinical trial
crisid: 4658
pmid: 27378000
related by: authorship_27360
volume: 44
chemicalscas: dexketoprofen, 22161-81-5; epinephrine, 51-43-4, 55-31-2, 6912-68-1; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; ketoprofen, 22071-15-4, 57495-14-4; trometamol, 1185-53-1, 77-86-1; Anti-Inflammatory Agents, Non-Steroidal; dexketoprofen trometamol; Ketoprofen; Tromethamine
related by: authorship_27357
freetext keyword: Dexketoprofen trometamol; Human pain model; Pre-emptive analgesia; Third molar surgery dexketoprofen; epinephrine; lidocaine; dexketoprofen; ketoprofen; nonsteroid antiinflammatory agent; trometamol; adult; Article; controlled study; dental surgery; drug efficacy; female; human; Kaplan Meier method; major clinical study; male; medical decision making; mixed model repeated measure; molar tooth; pain assessment; pain intensity; postoperative period; preoperative period; randomized controlled trial; statistical analysis; unspecified side effect; Wilcoxon signed ranks test; adolescent; analgesia; analogs and derivatives; comparative study; double blind procedure; molar tooth; pain measurement; Pain, Postoperative; prospective study; surgery; tooth extraction; treatment outcome; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ketoprofen; Male; Molar, Third; Pain Management; Pain Measurement; Pain, Postoperative; Prospective Studies; Tooth Extraction; Treatment Outcome; Tromethamine
type: Document
page end: 1355
type: Generically Dependent Continuant
origen: scopus
tradenames: dexketoprofen trometamol, Stein
related by: authorship_27359
most specific type: Document
related by: authorship_27355
type: Thing
has publication venue: Journal of Cranio-Maxillofacial Surgery
date time value: article date 4658
type: Article
related by: authorship_27356
page start: 1350
abstract: The aim of this study was to compare the efficacy of preoperative and postoperative dexketoprofen trometamol for pain control after third molar surgery. Sixty subjects indicated for impacted mandibular third molar surgery were randomly assigned to two groups: preoperative (group 1, n = 30) and postoperative (group 2, n = 30) administration. Group 1 received 25 mg of dexketoprofen trometamol 30 min before surgery and 1 placebo capsule (same color and size with active drug) immediately after surgery. Group 2 received the placebo capsule 30 min before surgery and 25 mg of dexketoprofen trometamol immediately after surgery. Pain intensity was assessed using a numeric rating scale (NRS) during the first 8 h. The time of the need for a second dose of dexketoprofen trometamol, after the first administration, was recorded. The data were analyzed using mixed-model repeated-measures (MMRM), Wilcoxon rank-sum, and Kaplan–Meier analysis. After the 8 h period, no statistically significant difference was observed in the intensity of pain (MMRM, p = 0.41); and no significant difference in the time for a second dose (p = 0.956). In conclusion, preoperative administration of dexketoprofen trometamol is a reasonable clinical approach that is as effective as conventional postoperative pharmacological treatment, with the advantage of allowing early analgesia before pain develops. (ClinicalTrials.gov: NCT02380001). © 2016 European Association for Cranio-Maxillo-Facial Surgery
manufactures: Stein
doi: 10.1016/j.jcms.2016.06.002
type: Information Content Entity
e iscopus: 2-s2.0-84999084676
related by: authorship_27361
type: Entity
related by: authorship_27358
estado: published
most specific type: Article
type: Continuant
issue: 9

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date: 2026-08-24T21:51:24
publisher: vivo
type: Document
label: RDF description of Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: A randomized clinical trial - http://orbis.uaslp.mx/vivo/individual/scopus4657

Article
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Journal of Cranio-Maxillofacial Surgery
type: Document
type: Continuant
type: Journal
type: Information Content Entity
type: Thing
type: Periodical
type: Collection
type: Entity
type: Generically Dependent Continuant
publication venue for: Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: A randomized clinical trial