Document
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Journal of Neurology, Neurosurgery and Psychiatry
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type: Generically Dependent Continuant
type: Continuant
type: Information Content Entity
type: Document
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type: Periodical
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publication venue for: Clinical outcomes and risk factors for Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: A multicentric case-control study
type: Journal

Clinical outcomes and risk factors for Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: A multicentric case-control study
crisid: 4565
page start: 287
type: Article
date time value: article date 4565
type: Document
related by: authorship_26829
estado: published
type: Information Content Entity
doi: 10.1136/jnnp-2014-310145
type: Continuant
volume: 87
related by: authorship_26835
related by: authorship_26831
has publication venue: Journal of Neurology, Neurosurgery and Psychiatry
related by: authorship_26827
related by: authorship_26836
e iscopus: 2-s2.0-84929587135
related by: authorship_26832
freetext keyword: creatinine; cyclophosphamide; hemoglobin; nitrogen; prednisone; urea; adrenal hyperplasia; age; antiphospholipid syndrome; Article; autoimmune disease; comorbidity; controlled study; creatinine blood level; diabetes mellitus; dyslipidemia; endothelial dysfunction; esophagus rupture; female; human; hypertension; immunosuppressive treatment; infection; ischemic heart disease; kidney disease; kidney failure; laboratory test; leukocyte count; lung hemorrhage; lymphocytopenia; major clinical study; male; Mexico; multicenter study; nuclear magnetic resonance imaging; outcome assessment; posterior reversible encephalopathy syndrome; preeclampsia; priority journal; retrospective study; risk factor; seizure; SLEDAI; smoking; systemic lupus erythematosus; urea nitrogen blood level; adult; case control study; clinical trial; disease course; Dyslipidemias; Lupus Erythematosus, Systemic; Lymphopenia; Posterior Leukoencephalopathy Syndrome; young adult; Adult; Case-Control Studies; Comorbidity; Disease Progression; Dyslipidemias; Female; Humans; Lupus Erythematosus, Systemic; Lymphopenia; Male; Mexico; Posterior Leukoencephalopathy Syndrome; Retrospective Studies; Risk Factors; Young Adult
chemicalscas: creatinine, 19230-81-0, 60-27-5; cyclophosphamide, 50-18-0; hemoglobin, 9008-02-0; nitrogen, 7727-37-9; prednisone, 53-03-2; urea, 57-13-6
related by: authorship_26828
pmid: 25804426
origen: scopus
type: Entity
most specific type: Article
related by: authorship_26833
page end: 294
type: Thing
issue: 3
type: Generically Dependent Continuant
abstract: Background: Posterior reversible encephalopathy syndrome (PRES) is a well-known but rare complication in patients (<1%25) with systemic lupus erythematosus (SLE). However, current epidemiological data are quite scant. The aim of the present study was to describe potentially unrecognised risk factors. Patients and methods: We performed a multicentre, retrospective case-control study in Mexico between 1999 and 2014. We included a total of 168 patients who accounted for 77 episodes of PRES, as follows: SLE/PRES, 43 patients with 48 episodes; SLE without PRES, 96 patients; and PRES without SLE, 29 patients. SLE diagnosis was considered when patients fulfilled ≥4 American College of Rheumatology criteria. PRES was defined by reversible neurological manifestations and MRI changes. Results: Patients with SLE/PRES were younger, presented with seizures as the most common manifestation (81%25) and 18%25 had the typical occipital MRI finding. Hypertension (OR=16.3, 95%25 CI 4.03 to 65.8), renal dysfunction (OR=6.65, 95%25 CI 1.24 to 35.6), lymphopenia (OR=5.76, 95%25 CI 1.36 to 24.4), Systemic Lupus Erythematosus Activity Index ≥ 6 points (OR=1.11, 95%25 CI 1.01 to 1.22) and younger age (OR=0.86, 95%25 CI 0.81 to 0.91, p<0.001) were independent risk factors for development of PRES in SLE. Furthermore, dyslipidemia also characterised the association between PRES and SLE (OR=10.6, 95%25 CI 1.17 to 96.4). Conclusions P:This is the largest reported series of patients with SLE and PRES. We were able to corroborate the known risk factors for of PRES, and found two previously undescribed factors (lymphopenia and dyslipidemia), which suggests that endothelial dysfunction is a key element in PRES pathogenesis in lupus patients.
related by: authorship_26834
related by: authorship_26830
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date: 2026-08-24T21:49:43
publisher: vivo
type: Document
label: RDF description of Clinical outcomes and risk factors for Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: A multicentric case-control study - http://orbis.uaslp.mx/vivo/individual/scopus4564

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