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PLoS Medicine
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publication venue for: Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis
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Entity
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Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis
related by: authorship_26772
has funding vehicle: Medical Research Council, MRC: MC_U190088478, MC_UP_A900_1116, MC_UP_A900_1124
related by: authorship_26762
estado: published
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related by: authorship_26795
freetext keyword: adolescent; adult; Article; child; disease surveillance; hospitalization; human; infant; influenza; influenza A (H3N2); Influenza A virus (H1N1); influenza B; polymerase chain reaction; Southeast Asia; systematic review; epidemiological monitoring; female; health; Influenza, Human; male; preschool child; Respiratory Tract Diseases; statistics and numerical data; virology; Adolescent; Child; Child, Preschool; Epidemiological Monitoring; Female; Global Health; Hospitalization; Humans; Infant; Influenza, Human; Male; Respiratory Tract Diseases
pmid: 27011229
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volume: 13
type: Document
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crisid: 4562
abstract: Background: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has been used to estimate influenza burden. In this analysis, we use surveillance data to provide an estimate of influenza-associated hospitalizations among children worldwide. Methods and Findings: We aggregated data from a systematic review (n = 108) and surveillance platforms (n = 37) to calculate a pooled estimate of the proportion of samples collected from children hospitalized with respiratory illnesses and positive for influenza by age group (<6 mo, <1 y, <2 y, <5 y, 5–17 y, and <18 y). We applied this proportion to global estimates of acute lower respiratory infection hospitalizations among children aged <1 y and <5 y, to obtain the number and per capita rate of influenza-associated hospitalizations by geographic region and socio-economic status. Influenza was associated with 10%25 (95%25 CI 8%25–11%25) of respiratory hospitalizations in children <18 y worldwide, ranging from 5%25 (95%25 CI 3%25–7%25) among children <6 mo to 16%25 (95%25 CI 14%25–20%25) among children 5–17 y. On average, we estimated that influenza results in approximately 374,000 (95%25 CI 264,000 to 539,000) hospitalizations in children <1 y—of which 228,000 (95%25 CI 150,000 to 344,000) occur in children <6 mo—and 870,000 (95%25 CI 610,000 to 1,237,000) hospitalizations in children <5 y annually. Influenza-associated hospitalization rates were more than three times higher in developing countries than in industrialized countries (150/100,000 children/year versus 48/100,000). However, differences in hospitalization practices between settings are an important limitation in interpreting these findings. Conclusions: Influenza is an important contributor to respiratory hospitalizations among young children…
related by: authorship_26811
related by: authorship_26723
related by: authorship_26802
origen: scopus
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type: Generically Dependent Continuant
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doi: 10.1371/journal.pmed.1001977
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type: Information Content Entity
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type: Thing
type: Article
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issue: 3
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has publication venue: PLoS Medicine
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e iscopus: 2-s2.0-84962069655
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Document
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Medical Research Council, MRC: MC_U190088478, MC_UP_A900_1116, MC_UP_A900_1124
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funding vehicle for: Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis

Continuant
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Article
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Information Content Entity
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RDF description of Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis - http://orbis.uaslp.mx/vivo/individual/scopus4561
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date: 2026-08-24T21:53:42
publisher: vivo
type: Document