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Human neutrophil peptide-1 decreases during ageing in selected Mexican population
page end: 454
related by: authorship_26353
abstract: Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases. © 2015, Springer Science Business Media New York.
date time value: article date 4499
related by: authorship_26356
related by: authorship_26350
type: Information Content Entity
most specific type: Document
chemicalscas: alpha defensin, 251460-81-8; cathelicidin, 170006-50-5; myeloperoxidase; peroxidase, 9003-99-0; alpha-Defensins; human neutrophil peptide 1; IL37 protein, human; Interleukin-1; Peroxidase
type: Continuant
type: Document
related by: authorship_26354
type: Entity
type: Thing
abstract: Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases. © 2015, Springer Science%2bBusiness Media New York.
related by: authorship_26357
origen: scopus
related by: authorship_26351
freetext keyword: Ageing; Antimicrobial peptides; Elderly; HNP-1; Immunosenescence; LL-37 alpha defensin; cathelicidin; cathelicidin antimicrobial peptide LL 37; human neutrophil peptide 1; messenger RNA; myeloperoxidase; unclassified drug; alpha defensin; human neutrophil peptide 1; IL37 protein, human; interleukin 1; peroxidase; adult; aged; aging; Article; bactericidal activity; controlled study; enzyme activity; human; human cell; Mexican; normal human; phagocytosis; priority journal; protein expression; protein synthesis; aging; female; gene expression; genetics; immunology; innate immunity; intracellular space; male; metabolism; mononuclear cell; neutrophil; very elderly; Adult; Aged; Aged, 80 and over; Aging; alpha-Defensins; Female; Gene Expression; Humans; Immunity, Innate; Interleukin-1; Intracellular Space; Leukocytes, Mononuclear; Male; Neutrophils; Peroxidase; Phagocytosis
pmid: 26323500
crisid: 4499
issue: 2
page start: 445
related by: authorship_26355
related by: authorship_26352
type: Article
e iscopus: 2-s2.0-84961184336
estado: published
type: Generically Dependent Continuant
volume: 64
most specific type: Article
has publication venue: Immunologic Research
doi: 10.1007/s12026-015-8689-2

Continuant
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Generically Dependent Continuant
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Immunologic Research
type: Generically Dependent Continuant
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publication venue for: Human neutrophil peptide-1 decreases during ageing in selected Mexican population

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date: 2026-08-24T21:45:37
publisher: vivo
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