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Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases. © 2015, Springer Science Business Media New York.
alpha defensin, 251460-81-8; cathelicidin, 170006-50-5; myeloperoxidase; peroxidase, 9003-99-0; alpha-Defensins; human neutrophil peptide 1; IL37 protein, human; Interleukin-1; Peroxidase
Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has not been described. In the present study, we addressed the question whether antimicrobial activity in polymorphonuclear cells from elderly individuals was altered in comparison with young adults. We compared phagocytosis index, bacterial killing efficiency, myeloperoxidase activity and cathelicidin expression. Results showed that there were no statistical differences among groups. However, human neutrophil peptide-1 (HNP-1) was decreased in the elderly individuals group. Results suggest that the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases. © 2015, Springer Science%2bBusiness Media New York.
Ageing; Antimicrobial peptides; Elderly; HNP-1; Immunosenescence; LL-37 alpha defensin; cathelicidin; cathelicidin antimicrobial peptide LL 37; human neutrophil peptide 1; messenger RNA; myeloperoxidase; unclassified drug; alpha defensin; human neutrophil peptide 1; IL37 protein, human; interleukin 1; peroxidase; adult; aged; aging; Article; bactericidal activity; controlled study; enzyme activity; human; human cell; Mexican; normal human; phagocytosis; priority journal; protein expression; protein synthesis; aging; female; gene expression; genetics; immunology; innate immunity; intracellular space; male; metabolism; mononuclear cell; neutrophil; very elderly; Adult; Aged; Aged, 80 and over; Aging; alpha-Defensins; Female; Gene Expression; Humans; Immunity, Innate; Interleukin-1; Intracellular Space; Leukocytes, Mononuclear; Male; Neutrophils; Peroxidase; Phagocytosis
Human neutrophil peptide-1 decreases during ageing in selected Mexican population
Generically Dependent Continuant
RDF description of Human neutrophil peptide-1 decreases during ageing in selected Mexican population - http://orbis.uaslp.mx/vivo/individual/scopus4498
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