Document
Natural Sciences and Engineering Research Council of Canada, NSERC: 268070, 219859-290917, 290749
Generically Dependent Continuant
The influence of catalysts on the addition of methoxy- and fluoroanilines with 1,4-naphthoquinone to give methoxy- and fluoro-substituted 2-(anilino)-1,4-naphthoquinones was investigated. In the absence of a catalyst, this reaction requires long times and low yields of the anilino derivatives are obtained accompanied with the formation of several secondary products. Excellent yields were obtained with a catalytic amount of a Lewis acid with strong oxidation properties such as CeCl3 or FeCl3. Excellent yields were also obtained when the reaction was performed with a Brønsted acid/oxidant mixture such as AcOH/Cu(OAc)2. This addition reaction was also investigated using microwave irradiation. A discussion on reaction conditions and mechanism is presented. The 1H and 13C NMR data of all the derivatives were analyzed and assigned using two dimensional 1H-13C gHSQC and gHMBC NMR experiments. The effect of fluorine substitution on redox and NMR properties was also investigated. © 2015 Elsevier B.V. All rights reserved.
2-(Fluoro-) and 2-(methoxyanilino)-1,4-naphthoquinones. Synthesis and mechanism and effect of fluorine substitution on redox reactivity and NMR
2-(Fluoroanilino)-1,4-naphthoquinone; Bifurcated hydrogen bond; Cu(OAc)2/AcOH; FeCl3; Lewis acid catalyst; Microwave; Redox potential; Strong oxidizing agent
RDF description of 2-(Fluoro-) and 2-(methoxyanilino)-1,4-naphthoquinones. Synthesis and mechanism and effect of fluorine substitution on redox reactivity and NMR - http://orbis.uaslp.mx/vivo/individual/scopus4370
Article
Consejo Nacional de Ciencia y Tecnología, CONACYT: 155678
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