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Journal of Clinical Immunology
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publication venue for: Natural killer cell-mediated activity in mixed connective tissue disease and its response to induction by interleukin-2
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RDF description of Natural killer cell-mediated activity in mixed connective tissue disease and its response to induction by interleukin-2 - http://orbis.uaslp.mx/vivo/individual/scopus43
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date: 2026-08-24T21:51:23
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Natural killer cell-mediated activity in mixed connective tissue disease and its response to induction by interleukin-2
related by: authorship 133
related by: authorship 130
freetext keyword: IL-2; mixed connective tissue disease; NK cell interleukin 2; blood and hemopoietic system; clinical article; mixed connective tissue disease; natural killer cell; soft tissue; Adult; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Immunologic; Female; Human; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Middle Age; Mixed Connective Tissue Disease; Support, Non-U.S. Gov't
date time value: article date 44
has publication venue: Journal of Clinical Immunology
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volume: 4
e iscopus: 2-s2.0-0021638137
related by: authorship 131
type: Document
pmid: 6611347
abstract: We studied natural killer cell-mediated (NKCM) activity and its enhancement by interleukin-2 (IL-2) in 15 patients with mixed connective tissue disease (MCTD). The mean baseline NKCM activity of peripheral blood mononuclear cells (MNC) against K562 target cells in the51Cr release assay was found to be similar to that found in age/sexmatched controls. MCTD patients%27 cells, however, responded significatively less to IL-2 induction of NKCM than did those of the controls. Using the single-cell agarose NK assay, we found that MCTD patients have a small number of active NK cells that exhibit a high rate of recycling capacity in the baseline state. These preactivated cells could not be stimulated further by IL-2. In two MCTD patients the response to IL-2 was nil, and in the serum from both of them we found an IgM inhibitory factor of such IL-2-induced enhancement. This factor could be absorbed only partially by normal MNC and NK cell-depleted MNC but completely by an IL-2-dependent T-cell line, suggesting that the inhibitory factor may be acting on the IL-2 receptor. These findings seem to be different from those reported in systemic lupus erythematosus and strengthen the notion that MCTD is due to a different immunoregulatory aberration. © 1984 Plenum Publishing Corporation.
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crisid: 44
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estado: published
chemicalscas: interleukin 2, 85898-30-2; Interleukin-2
issue: 4
page start: 273
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related by: authorship 132
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page end: 279
doi: 10.1007/BF00915294
abstract: We studied natural killer cell-mediated (NKCM) activity and its enhancement by interleukin-2 (IL-2) in 15 patients with mixed connective tissue disease (MCTD). The mean baseline NKCM activity of peripheral blood mononuclear cells (MNC) against K562 target cells in the51Cr release assay was found to be similar to that found in age/sexmatched controls. MCTD patients' cells, however, responded significatively less to IL-2 induction of NKCM than did those of the controls. Using the single-cell agarose NK assay, we found that MCTD patients have a small number of active NK cells that exhibit a high rate of recycling capacity in the baseline state. These preactivated cells could not be stimulated further by IL-2. In two MCTD patients the response to IL-2 was nil, and in the serum from both of them we found an IgM inhibitory factor of such IL-2-induced enhancement. This factor could be absorbed only partially by normal MNC and NK cell-depleted MNC but completely by an IL-2-dependent T-cell line, suggesting that the inhibitory factor may be acting on the IL-2 receptor. These findings seem to be different from those reported in systemic lupus erythematosus and strengthen the notion that MCTD is due to a different immunoregulatory aberration. © 1984 Plenum Publishing Corporation.
type: Generically Dependent Continuant
origen: scopus