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RDF description of IgG4-related disease, retrospective histopathological diagnosis. Prevalence in a University Hospital [Enfermedades relacionadas con IgG4, diagnóstico histopatológico retrospectivo. Prevalencia en un hospital universitario] - http://orbis.uaslp.mx/vivo/individual/scopus4191
Introduction: IgG4 related diseases (IgG4-RD) are characterized mainly by organic dysfunction and inflammation with lymphoplasmacytic cells infiltration. Methods: We conducted a retrospective study. We analyzed patients with a diagnosis of IgG4-RD through histopathologic registries. We divided the study into three phases: (i) extraction of data from the registries of the Pathology Department, including specimens reported with: non-specific inflammation with plasmatic cell infiltration, inflammatory pseudo-tumors and storiform fibrosis, and excluding any report of cancer or infection; (ii) from the selected specimens, three pathologists microscopically re-analyzed these biopsies and included only those who had at least two of the inclusion criteria cited above; (iii) finally, immunostaining was performed in the specimens selected in the second phase. The selected biopsies were catalogued as compatible for IgG4-RD if they had at least 3 inclusion criteria and as probable if they had 2 inclusion criteria. Results: On the first phase of the study we analyzed 23,720 biopsies, from which we included 71 and excluded 29 specimens; the rest of the specimens (n = 41) underwent immunostaining. From the biopsies included, 41.4%25 (n = 17/71) were positive to IgG4, with the most common histological diagnosis for the positive specimens being granulomatous mastitis, which represented 12.1%25 of the specimens catalogued initially as probable. The rest of the positive biopsies were from aortitis, dacrioadenitis and/or sialoadenitis, lung pseudo-inflammatory tumor, pericarditis and chronic pancreatitis. Conclusions: The suspicion of IgG4 related disease should not be based solely on clinical manifestations or serology. In the present study we confirm the characteristic changes of IgG4-RD in patients without initial clinical suspicion. © 2014 Elsevier España, S.L.U.
IgG4-related disease, retrospective histopathological diagnosis. Prevalence in a University Hospital [Enfermedades relacionadas con IgG4, diagnóstico histopatológico retrospectivo. Prevalencia en un hospital universitario]
Chronic sialoadenitis; Granulomatous mastitis; IgG4 related disease; Inflammatory tumor aortitis; Article; chronic pancreatitis; controlled study; dacryocystitis; granulomatous mastitis; histopathology; human; human tissue; immunoglobulin G4 related disease; lung pseudotumor; major clinical study; pericarditis; prevalence; retrospective study; sialoadenitis; university hospital; adolescent; adult; aged; Autoimmune Diseases; biopsy; child; female; immunology; male; metabolism; Mexico; middle aged; pathology; young adult; biological marker; immunoglobulin G; Adolescent; Adult; Aged; Autoimmune Diseases; Biomarkers; Biopsy; Child; Female; Hospitals, University; Humans; Immunoglobulin G; Male; Mexico; Middle Aged; Prevalence; Retrospective Studies; Young Adult
immunoglobulin G, 97794-27-9; Biomarkers; Immunoglobulin G
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