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RDF description of Factors associated with mortality and infections in patients with systemic lupus erythematosus with diffuse alveolar hemorrhage - http://orbis.uaslp.mx/vivo/individual/scopus3867
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Diffuse alveolar hemorrhage; Infections; Mortality; Systemic lupus erythematosus C reactive protein; C reactive protein; adult; adult disease; APACHE; article; artificial ventilation; bacterial infection; child; childhood disease; clinical article; clinical feature; controlled study; diffuse alveolar hemorrhage; disease association; female; human; hypocomplementemia; kidney failure; lung hemorrhage; male; medical record review; mortality; priority journal; recurrent disease; systemic lupus erythematosus; systemic mycosis; thrombocytopenia; adolescent; age; clinical trial; comorbidity; comparative study; complication; Hemorrhage; infection; lung alveolus; Lung Diseases; Lupus Erythematosus, Systemic; metabolism; multicenter study; register; retrospective study; risk factor; sex difference; survival rate; Adolescent; Adult; Age Factors; C-Reactive Protein; Child; Comorbidity; Female; Hemorrhage; Humans; Infection; Lung Diseases; Lupus Erythematosus, Systemic; Male; Pulmonary Alveoli; Registries; Renal Insufficiency; Respiration, Artificial; Retrospective Studies; Risk Factors; Sex Factors; Survival Rate; Thrombocytopenia
C reactive protein, 9007-41-4; C-Reactive Protein
Objective: To evaluate factors associated with mortality and infections in patients with systemic lupus erythematosus (SLE) and diffuse alveolar hemorrhage (DAH). Methods: A retrospective chart review was carried out for medical admissions of patients with a diagnosis of SLE and DAH in 9 hospitals. Clinical and laboratory data were recorded for each patient at DAH diagnosis. Results: We included 57 episodes of DAH of 50 patients (7 recurrences), 49 women (86%25), 14 juvenile SLE (24.6%25); 24 had died (42.1%25). In the chart review we detected infection in 22 episodes (38.6%25): 8 invasive fungal infections, 16 bacterial infections, and 2 patients had both types. In the bivariate analysis, factors associated with mortality were high Acute Physiology and Chronic Health Evaluation II scores, requirement of mechanical ventilation (OR 15.0, 95%25 CI 1.9 to 662.2), infections (fungal or bacterial; OR 3.2, CI 0.9 to 11.1), renal failure (OR 4.9, CI 1.4 to 18.0), and thrombocytopenia (OR 4.3, CI 1.2 to 15.6). We found similar mortality between children and adults. Infections were associated with treatment for SLE, requirement of mechanical ventilation, hypocomplementemia, and high levels of C-reactive protein. Conclusion: Infection is a frequent finding in patients with DAH and SLE; we found similar mortality between adult SLE and juvenile SLE. Factors that we describe associated with infections may influence the therapeutic selection for these patients. Copyright © 2014. All rights reserved.
Factors associated with mortality and infections in patients with systemic lupus erythematosus with diffuse alveolar hemorrhage
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