Document
type: Class

Toxicology Letters
publication venue for: Silver nanoparticles induce anti-proliferative effects on airway smooth muscle cells. Role of nitric oxide and muscarinic receptor signaling pathway
type: Thing
type: Generically Dependent Continuant
type: Periodical
type: Collection
type: Information Content Entity
type: Document
type: Journal
type: Entity
type: Continuant

Continuant
type: Class

Entity
type: Class

407087
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Silver nanoparticles induce anti-proliferative effects on airway smooth muscle cells. Role of nitric oxide and muscarinic receptor signaling pathway

Generically Dependent Continuant
type: Class

Silver nanoparticles induce anti-proliferative effects on airway smooth muscle cells. Role of nitric oxide and muscarinic receptor signaling pathway
type: Information Content Entity
related by: authorship_21501
e iscopus: 2-s2.0-84888406607
type: Entity
related by: authorship_21500
page end: 256
page start: 246
abstract: Silver nanoparticles (AgNPs) are used to manufacture materials with new properties and functions. However, little is known about their toxic or beneficial effects on human health, especially in the respiratory system, where its smooth muscle (ASM) regulates the airway contractility by different mediators, such as acetylcholine (ACh) and nitric oxide (NO). The aim of this study was to evaluate the effects of AgNPs on ASM cells. Exposure to AgNPs induced ACh-independent expression of the inducible nitric oxide synthase (iNOS) at 100. μg/mL, associated with excessive production of NO. AgNPs induced the muscarinic receptor activation, since its blockage with atropine and blockage of its downstream signaling pathway inhibited the NO production. AgNPs at 10 and 100. μg/mL induced ACh-independent prolonged cytotoxicity and decreased cellular proliferation mediated by the muscarinic receptor-iNOS pathway. However, the concentration of 100. μg/mL of AgNPs induced muscarinic receptor-independent apoptosis, suggesting the activation of multiple pathways. These data indicate that AgNPs induce prolonged cytotoxic and anti-proliferative effects on ASM cells, suggesting an activation of the muscarinic receptor-iNOS pathway. Further investigation is required to understand the full mechanisms of action of AgNPs on ASM under specific biological conditions. © 2013 Elsevier Ireland Ltd.
issue: 2
most specific type: Article
type: Thing
related by: authorship_21503
freetext keyword: Airway; Apoptosis; Muscarinic receptor; Nitric oxide; Proliferation; Silver nanoparticles acetylcholine; atropine; inducible nitric oxide synthase; muscarinic receptor; nitric oxide; silver nanoparticle; animal cell; antiproliferative activity; apoptosis; article; cell proliferation; clinical evaluation; controlled study; cytotoxicity; enzyme activation; male; muscle contractility; nonhuman; priority journal; protein expression; rat; respiratory system; signal transduction; smooth muscle; smooth muscle fiber; Airway; Apoptosis; Muscarinic receptor; Nitric oxide; Proliferation; Silver nanoparticles; Acetylcholine; Animals; Apoptosis; Cell Proliferation; Male; Metal Nanoparticles; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Receptors, Muscarinic; Signal Transduction; Silver; Trachea
related by: authorship_21502
type: Continuant
related by: authorship_21498
chemicalscas: acetylcholine, 51-84-3, 60-31-1, 66-23-9; atropine, 51-55-8, 55-48-1; inducible nitric oxide synthase, 501433-35-8; nitric oxide, 10102-43-9; Acetylcholine, N9YNS0M02X; Nitric Oxide, 31C4KY9ESH; Nitric Oxide Synthase Type II, 1.14.13.39; Receptors, Muscarinic; Silver, 3M4G523W1G
type: Document
type: Article
related by: authorship_21497
pmid: 24188929
estado: published
related by: authorship_21504
type: Generically Dependent Continuant
doi: 10.1016/j.toxlet.2013.10.027
most specific type: Document
date time value: article date 3739
crisid: 3739
has publication venue: Toxicology Letters
origen: scopus
has funding vehicle: 407087
volume: 224
related by: authorship_21499

individual
rights: termsOfUse
date: 2026-08-24T21:50:50
publisher: vivo
type: Document
label: RDF description of Silver nanoparticles induce anti-proliferative effects on airway smooth muscle cells. Role of nitric oxide and muscarinic receptor signaling pathway - http://orbis.uaslp.mx/vivo/individual/scopus3738

Article
type: Class

Information Content Entity
type: Class