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Diazides; Fluoroarylazide; Microwave; Photoaffinity labeling
Microwave-assisted synthesis of substituted fluorophenyl mono- and diazides by SNAr. A fast methodology to prepare photoaffinity labeling and crosslinking reagents
The reaction of sodium azide with perfluorobenzene, containing an electron-withdrawing group, under microwave irradiation results in the fast preparation of p-substituted tetrafluorophenyl monoazides. Having an excess of sodium azide and a strong electron-withdrawing group like NO2 or CN, fluorophenyl diazides are also produced upon conventional or microwave heating. A synergic effect between the amount of sodium azide and the electron-withdrawing character of the substituents is observed giving different products. A discussion on the products and reaction mechanism is presented. © 2013 Published by Elsevier B.V.
Generically Dependent Continuant
RDF description of Microwave-assisted synthesis of substituted fluorophenyl mono- and diazides by SNAr. A fast methodology to prepare photoaffinity labeling and crosslinking reagents - http://orbis.uaslp.mx/vivo/individual/scopus3638
University of California, Los Angeles, UCLA
Article
Consejo Nacional de Ciencia y Tecnología, CONACYT: 290618, CB-2010-155678
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