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Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: A reverse translational rat study
type: Information Content Entity
doi: 10.1590/1414-431X20132834
most specific type: Document
page end: 880
freetext keyword: Aortic barodenervation; Nitric oxide bioavailability; Salt-sensitive hypertension messenger RNA; nitric oxide; reduced nicotinamide adenine dinucleotide phosphate oxidase; superoxide; superoxide dismutase; animal experiment; animal model; animal tissue; aorta pressoreceptor; article; bioavailability; blood pressure; body weight; catheter; controlled study; heart denervation; high sodium intake; hypertension; kidney medulla; male; mean arterial pressure; nonhuman; pressoreceptor; rat; reverse transcription polymerase chain reaction; RNA translation; sensitivity analysis; sodium intake; sodium restriction; spectrophotometry; translational research
related by: authorship_20328
type: Continuant
page start: 868
issue: 10
most specific type: Article
abstract: This study determined whether clinical salt-sensitive hypertension (cSSHT) results from the interaction between partial arterial baroreceptor impairment and a high-sodium (HNa) diet. In three series (S-I, S-II, S-III), mean arterial pressure (MAP) of conscious male Wistar ChR003 rats was measured once before (pdMAP) and twice after either sham (SHM) or bilateral aortic denervation (AD), following 7 days on a low-sodium (LNa) diet (LNaMAP) and then 21 days on a HNa diet (HNaMAP). The roles of plasma nitric oxide bioavailability (pNOB), renal medullary superoxide anion production (RMSAP), and mRNA expression of NAD(P)H oxidase and superoxide dismutase were also assessed. In SHM (n=11) and AD (n=15) groups of S-I, LNaMAP-pdMAP was 10.5±2.1 vs 23±2.1 mmHg (P<0.001), and the salt-sensitivity index (SSi; HNaMAP-LNaMAP) was 6.0±1.9 vs 12.7±1.9 mmHg (P=0.03), respectively. In the SHM group, all rats were normotensive, and 36%25 were salt sensitive (SSi≥10 mmHg), whereas in the AD group ~50%25 showed cSSHT. A 45%25 reduction in pNOB (P≤0.004) was observed in both groups in dietary transit. RMSAP increased in the AD group on both diets but more so on the HNa diet (S-II, P<0.03) than on the LNa diet (S-III, P<0.04). MAP modeling in rats without a renal hypertensive genotype indicated that the AD*HNa diet interaction (P=0.008) increases the likelihood of developing cSSHT. Translationally, these findings help to explain why subjects with clinical salt-sensitive normotension may transition to cSSHT.
date time value: article date 3529
estado: published
volume: 46
related by: authorship_20326
related by: authorship_20329
type: Generically Dependent Continuant
type: Thing
has publication venue: Brazilian Journal of Medical and Biological Research
type: Article
e iscopus: 2-s2.0-84886899362
type: Entity
chemicalscas: nitric oxide, 10102-43-9; reduced nicotinamide adenine dinucleotide phosphate oxidase, 9032-22-8; superoxide, 11062-77-4; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1
related by: authorship_20324
related by: authorship_20327
type: Document
related by: authorship_20325
accesstype: All Open Access, Gold, Green
origen: scopus
crisid: 3529

Brazilian Journal of Medical and Biological Research
type: Periodical
type: Collection
publication venue for: Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: A reverse translational rat study
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type: Information Content Entity
type: Journal
type: Continuant
type: Thing
type: Generically Dependent Continuant
type: Entity

Generically Dependent Continuant
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individual
rights: termsOfUse
date: 2026-08-24T21:51:02
publisher: vivo
type: Document
label: RDF description of Partial baroreceptor dysfunction and low plasma nitric oxide bioavailability as determinants of salt-sensitive hypertension: A reverse translational rat study - http://orbis.uaslp.mx/vivo/individual/scopus3528

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