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Instituto Nacional de Medicina Genómica, INMEGEN
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funding vehicle for: The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: A case-control study

RDF description of The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: A case-control study - http://orbis.uaslp.mx/vivo/individual/scopus3467
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date: 2026-08-24T21:50:49
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Article
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Journal of Orthopaedic Science
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publication venue for: The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: A case-control study

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The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: A case-control study
crisid: 3468
has publication venue: Journal of Orthopaedic Science
related by: authorship_20008
date time value: article date 3468
most specific type: Article
related by: authorship_20005
estado: published
type: Document
e iscopus: 2-s2.0-84885468342
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abstract: Background: A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described among the Mexican mestizo population. The aim of this study was to analyze the association of the ASPN gene D-repeat polymorphism in a Mexican mestizo population with primary knee OA as well as in healthy controls. Materials and methods: A case-control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables. Results: After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor. Conclusions: These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population. © 2013 The Japanese Orthopaedic Association.
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related by: authorship_20007
most specific type: Document
type: Generically Dependent Continuant
origen: scopus
type: Information Content Entity
page end: 831
page start: 826
type: Article
pmid: 23733110
type: Continuant
related by: authorship_20009
freetext keyword: adult; article; aspartic acid repeat polymorphism; asporin gene; case control study; clinical feature; controlled study; ethnic group; female; gene; gene frequency; genetic association; genetic polymorphism; genetic risk; genetic susceptibility; genotype; human; knee osteoarthritis; major clinical study; male; Mexican mestizo; molecular pathology; risk assessment; Case-Control Studies; Extracellular Matrix Proteins; Female; Humans; Male; Mexico; Middle Aged; Osteoarthritis, Knee; Polymorphism, Genetic
related by: authorship_20004
issue: 5
doi: 10.1007/s00776-013-0414-1
has funding vehicle: Instituto Nacional de Medicina Genómica, INMEGEN
related by: authorship_20006
volume: 18