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Generically Dependent Continuant
Instituto Nacional de Medicina Genómica, INMEGEN
RDF description of The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: A case-control study - http://orbis.uaslp.mx/vivo/individual/scopus3467
Article
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Background: A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described among the Mexican mestizo population. The aim of this study was to analyze the association of the ASPN gene D-repeat polymorphism in a Mexican mestizo population with primary knee OA as well as in healthy controls. Materials and methods: A case-control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables. Results: After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor. Conclusions: These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population. © 2013 The Japanese Orthopaedic Association.
The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: A case-control study
adult; article; aspartic acid repeat polymorphism; asporin gene; case control study; clinical feature; controlled study; ethnic group; female; gene; gene frequency; genetic association; genetic polymorphism; genetic risk; genetic susceptibility; genotype; human; knee osteoarthritis; major clinical study; male; Mexican mestizo; molecular pathology; risk assessment; Case-Control Studies; Extracellular Matrix Proteins; Female; Humans; Male; Mexico; Middle Aged; Osteoarthritis, Knee; Polymorphism, Genetic