Document
type: Class

Continuant
type: Class

Entity
type: Class

Generically Dependent Continuant
type: Class

RDF description of Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles - http://orbis.uaslp.mx/vivo/individual/scopus3388
rights: termsOfUse
date: 2026-08-26T23:56:26
publisher: vivo
type: Document

Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles
related by: authorship_19593
abstract: Aim: Infections associated with medical devices are an important cause of morbidity and mortality. Microorganisms are responsible for catheter infections that may then result in the local or systemic dissemination of the microorganism into the bloodstream. The aim of this study was to evaluate the antimicrobial activity of silver nanoparticles (AgNPs) embedded in polyurethane plastics, commonly used for catheter fabrication. Materials & methods: AgNPs in the range of 25-30 nm were synthesized and embedded in polyurethane plastics at different concentrations. The antimicrobial activities of these plastics were tested against the three pathogenic microorganisms, Escherichia coli, Staphylococcus epidermidis and Candida albicans, frequently associated with catheter infections. The cytotoxicity of the plastics was evaluated on human-derived macrophages using propidium iodide and the secretion of the pro- and anti-inflammatory cytokines IL-6, IL-10 and TNF-a was measured using ELISA. Results: A significant reduction of 6- to 7-log in the number of bacteria was measured, while a reduction of 90%25 was measured in the case of C. albicans. Neither cytotoxic effect on macrophages nor immunological response was observed. Conclusion: Plastics embedded with AgNPs have great potential to limit microbial colonization of implanted medical devices. © 2013 Future Medicine Ltd.
date time value: article date 3389
type: Generically Dependent Continuant
volume: 8
freetext keyword: antimicrobial activity; cytotoxicity; immunological response; medical devices; silver nanoparticles interleukin 10; interleukin 6; plastic; propidium iodide; silver nanoparticle; tumor necrosis factor alpha; antiinflammatory activity; antimicrobial activity; article; bacterial colonization; Candida albicans; enzyme linked immunosorbent assay; Escherichia coli; human; human cell; macrophage; medical device; priority journal; Staphylococcus aureus; Staphylococcus epidermidis
related by: authorship_19594
most specific type: Document
crisid: 3389
related by: authorship_19597
abstract: Aim: Infections associated with medical devices are an important cause of morbidity and mortality. Microorganisms are responsible for catheter infections that may then result in the local or systemic dissemination of the microorganism into the bloodstream. The aim of this study was to evaluate the antimicrobial activity of silver nanoparticles (AgNPs) embedded in polyurethane plastics, commonly used for catheter fabrication. Materials %26 methods: AgNPs in the range of 25-30 nm were synthesized and embedded in polyurethane plastics at different concentrations. The antimicrobial activities of these plastics were tested against the three pathogenic microorganisms, Escherichia coli, Staphylococcus epidermidis and Candida albicans, frequently associated with catheter infections. The cytotoxicity of the plastics was evaluated on human-derived macrophages using propidium iodide and the secretion of the pro- and anti-inflammatory cytokines IL-6, IL-10 and TNF-a was measured using ELISA. Results: A significant reduction of 6- to 7-log in the number of bacteria was measured, while a reduction of 90%25 was measured in the case of C. albicans. Neither cytotoxic effect on macrophages nor immunological response was observed. Conclusion: Plastics embedded with AgNPs have great potential to limit microbial colonization of implanted medical devices. © 2013 Future Medicine Ltd.
estado: published
related by: authorship_19600
type: Document
origen: scopus
related by: authorship_19599
type: Thing
related by: authorship_19592
doi: 10.2217/fmb.13.5
has publication venue: Future Microbiology
e iscopus: 2-s2.0-84874751981
page start: 403
type: Continuant
pmid: 23464375
chemicalscas: propidium iodide, 25535-16-4
page end: 411
related by: authorship_19595
related by: authorship_19596
type: Article
accesstype: All Open Access, Green
issue: 3
related by: authorship_19598
type: Information Content Entity
type: Entity
most specific type: Article

Article
type: Class

Future Microbiology
type: Continuant
type: Collection
publication venue for: Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles
type: Periodical
type: Entity
type: Information Content Entity
type: Thing
type: Generically Dependent Continuant
type: Journal
type: Document

Information Content Entity
type: Class