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RDF description of Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother-infant pairs of an agrarian community - http://orbis.uaslp.mx/vivo/individual/scopus3366
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date: 2026-08-24T21:45:40
publisher: vivo
type: Document

Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother-infant pairs of an agrarian community
related by: authorship_19501
related by: authorship_19499
type: Document
type: Article
type: Thing
abstract: Exposure to organochlorine pesticides was studied in a group of mother-infant pairs living in a rural area where agriculture is the main economic activity. Fumigation in this zone is performed with airplanes, thus affecting the inhabited areas around them, including schools. Heparinized venous blood of mothers and umbilical cords was used to evaluate the olive tail moment in the comet assay, and micronuclei, chromatin buds, and nucleoplasmic bridges in peripheral blood lymphocytes. Cord blood samples were taken at the moment of birth only from natural and normal parturitions. Determinations of hexachlorobenzene, aldrin, heptachlor epoxide, oxichlordane, t and c-chlordane, cis-nonachlor, mirex, alpha and beta-endosulfan, alpha, beta and gamma hexachlorocyclohexane, and p'p'-DDT, p'p'-DDE were conducted to establish the differential distribution of the toxicants between compartments, i.e., mother and umbilical cord. Significantly higher pesticide levels were found in umbilical cord plasma than in mothers' plasma for almost all compounds tested, except DDE and oxychlordane. Significantly higher olive tail moments were found in umbilical cords than in mothers, whereas micronuclei frequencies were higher in mothers than in umbilical cords. However, neither the levels of micronuclei nor the olive tail moment were correlated with pesticide levels. Given that no other exposure to toxic compounds has been identified in this region, the lack of correlation between genotoxicity biomarkers and pesticide levels may be due to the variability of the exposure and to endogenous processes related to lipid mobility during pregnancy, the metabolism of the compounds, and individual susceptibilities. © 2013 Wiley Periodicals, Inc.
estado: published
page start: 99
doi: 10.1002/em.21753
type: Continuant
crisid: 3367
issue: 2
abstract: Exposure to organochlorine pesticides was studied in a group of mother-infant pairs living in a rural area where agriculture is the main economic activity. Fumigation in this zone is performed with airplanes, thus affecting the inhabited areas around them, including schools. Heparinized venous blood of mothers and umbilical cords was used to evaluate the olive tail moment in the comet assay, and micronuclei, chromatin buds, and nucleoplasmic bridges in peripheral blood lymphocytes. Cord blood samples were taken at the moment of birth only from natural and normal parturitions. Determinations of hexachlorobenzene, aldrin, heptachlor epoxide, oxichlordane, t and c-chlordane, cis-nonachlor, mirex, alpha and beta-endosulfan, alpha, beta and gamma hexachlorocyclohexane, and p%27p%27-DDT, p%27p%27-DDE were conducted to establish the differential distribution of the toxicants between compartments, i.e., mother and umbilical cord. Significantly higher pesticide levels were found in umbilical cord plasma than in mothers%27 plasma for almost all compounds tested, except DDE and oxychlordane. Significantly higher olive tail moments were found in umbilical cords than in mothers, whereas micronuclei frequencies were higher in mothers than in umbilical cords. However, neither the levels of micronuclei nor the olive tail moment were correlated with pesticide levels. Given that no other exposure to toxic compounds has been identified in this region, the lack of correlation between genotoxicity biomarkers and pesticide levels may be due to the variability of the exposure and to endogenous processes related to lipid mobility during pregnancy, the metabolism of the compounds, and individual susceptibilities. © 2013 Wiley Periodicals, Inc.
e iscopus: 2-s2.0-84873253748
most specific type: Article
page end: 111
related by: authorship_19498
pmid: 23355095
volume: 54
related by: authorship_19496
related by: authorship_19500
type: Entity
related by: authorship_19497
type: Information Content Entity
type: Generically Dependent Continuant
freetext keyword: Generalized linear model; Genotoxic effects; Internal dose; Pesticide mixture; Umbilical cord 1,1 dichloro 2,2 bis(4 chlorophenyl)ethylene; aldrin; alpha hexachlorocyclohexane; beta hexachlorocyclohexane; biological marker; chlordane; chlorphenotane; endosulfan; heptachlor epoxide; hexachlorobenzene; lindane; mirex; nonachlor; organochlorine pesticide; agriculture; article; blood sampling; chromatin; comet assay; correlation analysis; DNA damage; environmental exposure; female; fumigation; genotoxicity; human; infant; micronucleus; peripheral lymphocyte; pregnancy; prenatal drug exposure; rural area; sampling; umbilical cord; Agriculture; Comet Assay; DNA Damage; Environmental Exposure; Environmental Monitoring; Female; Fetal Blood; Humans; Hydrocarbons, Chlorinated; Infant, Newborn; Limit of Detection; Lymphocytes; Maternal Exposure; Maternal-Fetal Exchange; Micronuclei, Chromosome-Defective; Micronucleus Tests; Pesticides; Pregnancy; Rural Population
has publication venue: Environmental and Molecular Mutagenesis
most specific type: Document
origen: scopus
date time value: article date 3367
chemicalscas: 1,1 dichloro 2,2 bis(4 chlorophenyl)ethylene, 72-55-9; aldrin, 257-55-6, 309-00-2; alpha hexachlorocyclohexane, 319-84-6; beta hexachlorocyclohexane, 319-85-7; chlordane, 12789-03-6, 57-74-9; chlorphenotane, 50-29-3; endosulfan, 115-29-7; heptachlor epoxide, 1024-57-3; hexachlorobenzene, 118-74-1, 55600-34-5; lindane, 58-89-9; mirex, 2385-85-5; nonachlor, 3734-49-4; Hydrocarbons, Chlorinated; Pesticides

Article
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Information Content Entity
type: Class

Environmental and Molecular Mutagenesis
type: Periodical
type: Entity
type: Continuant
type: Collection
type: Thing
publication venue for: Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother-infant pairs of an agrarian community
type: Document
type: Journal
type: Information Content Entity
type: Generically Dependent Continuant