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creatinine, 19230-81-0, 60-27-5; Creatinine, AYI8EX34EU; Cystatin C
Equations; Glomerular filtration rate; Systemic erythematosus lupus creatinine; cystatin C; adolescent; adult; aged; article; chronic kidney failure; female; glomerulus filtration rate; human; kidney function test; male; mathematics; metabolism; methodology; middle aged; pathophysiology; reproducibility; systemic lupus erythematosus; young adult; Adolescent; Adult; Aged; Creatinine; Cystatin C; Female; Glomerular Filtration Rate; Humans; Kidney Function Tests; Lupus Erythematosus, Systemic; Male; Mathematics; Middle Aged; Renal Insufficiency, Chronic; Reproducibility of Results; Young Adult
CKD-EPI is the most reliable equation to estimate renal function in patients with systemic lupus erythematosus
Background: No study has determined the best equation for estimating renal function in patients with systemic lupus erythematosus (SLE), starting from a gold standard test. Objective: To evaluate the performance of cistatin/creatinine based equations for estimating renal function in patients with SLE. Methods: We conducted two phases: the first phase included 14 patients in which iothalamate clearance was used to determine the glomerular filtration rate (GFR) and compared with different equations based on cystatin C and/or creatinine. In the second phase, we used the best equation (a cystatin and creatinine-based equation) as reference standard to compare 5 creatinine-based equations in 55 patients with SLE. Results: In the first phase the equation developed by Stevens and colleagues (based on creatinine and cystatin C), was the best equation. In phase 2, the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation was the best equation with bias of -2.1ml/min/1.73, accuracy (P30) of 94.5%25 and precision (interquartile range of differences) of -2.1 ml/min/1.73. Conclusions: Our data suggest that CKD-EPI is the best creatinine-based equation to estimate GFR in patients with SLE. © 2013 Revista Nefrología.
Generically Dependent Continuant
RDF description of CKD-EPI is the most reliable equation to estimate renal function in patients with systemic lupus erythematosus - http://orbis.uaslp.mx/vivo/individual/scopus3316
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